Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens
AK Zinsmaier, Y Dong, YH Huang - Molecular psychiatry, 2022 - nature.com
… area synapses, and (4) the input, output, subregion, and D1/D2 cell type may together
determine cocaine-induced … of operant responding, but rather regulates the conditioning of the …
determine cocaine-induced … of operant responding, but rather regulates the conditioning of the …
[HTML][HTML] CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired …
AS Guzman, MP Avalos, LN De Giovanni… - Scientific Reports, 2021 - nature.com
… in modulating the expression of conditioned drug seeking. … that the cocaine-induced increase
in extracellular glutamate may … that the context-specific elevation of extracellular glutamate …
in extracellular glutamate may … that the context-specific elevation of extracellular glutamate …
Molecular and circuit mechanisms regulating cocaine memory
BN Bender, MM Torregrossa - Cellular and Molecular Life Sciences, 2020 - Springer
… , and activation of brain regions associated with reward. Pavlovian conditioning results in …
Moreover, numerous intracellular signaling processes in the NAc have also been implicated …
Moreover, numerous intracellular signaling processes in the NAc have also been implicated …
… evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated …
LGSC Crespo, JBL Júnior, JM de Mello Bastos… - Pharmacology …, 2022 - Elsevier
… effects of morphine on extracellular signal regulated protein kinase activity (ERK) to assess
the effects of morphine on activation of subcortical brain areas implicated in dopaminergic …
the effects of morphine on activation of subcortical brain areas implicated in dopaminergic …
Context-specific tolerance and pharmacological changes in the infralimbic cortex-nucleus accumbens shell pathway evoked by ketamine
GK Silva-Cardoso, MJ Nobre - Neurochemical Research, 2021 - Springer
… associative learning through conditioning and later assess … during the assay of extracellular
concentration of dopamine and … drinkers and prevents cocaine-induced reinstatement [77]. …
concentration of dopamine and … drinkers and prevents cocaine-induced reinstatement [77]. …
Context-dependent and context-independent effects of D1 receptor antagonism in the basolateral and central amygdala during cocaine self-administration
… amounts of extracellular dopamine to efflux into limbic regions. The … drug paired
conditioned stimulus is presented. … in a persistent, context-specific attenuation of self-administration. …
conditioned stimulus is presented. … in a persistent, context-specific attenuation of self-administration. …
Intermittent access cocaine self-administration produces context-specific escalation and increased motivation
MM Beasley, BJ Tunstall, DN Kearns - Drug and Alcohol Dependence, 2023 - Elsevier
… under the skin to the midscapular region where it connected to the 22-gauge stainless steel
… 12 very large increases in striatal extracellular dopamine corresponding to the beginning of …
… 12 very large increases in striatal extracellular dopamine corresponding to the beginning of …
Dynamic dichotomy of accumbal population activity underlies cocaine sensitization
R van Zessen, Y Li, L Marion-Poll, N Hulo, J Flakowski… - Elife, 2021 - elifesciences.org
… Among the intracellular signaling cascades, the activation of … was sufficient to reverse
cocaine induced D1R SPN activity … accumbens neurons prevents context- specific sensitization. …
cocaine induced D1R SPN activity … accumbens neurons prevents context- specific sensitization. …
[HTML][HTML] Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation
… highly expressed in limbic and cortical areas [48]. Our group … CPP, as evidenced by the
development of conditioned place … that the increased basal levels of intracellular Ca 2+ , pAkt and …
development of conditioned place … that the increased basal levels of intracellular Ca 2+ , pAkt and …
Activity-dependent epigenetic remodeling in cocaine use disorder
… and channels and their associated intracellular effectors that … the acquisition of cocaine-conditioned
place preference (CPP… been specifically the cocaine-induced adaptations in plasticity…
place preference (CPP… been specifically the cocaine-induced adaptations in plasticity…