Advances in Aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders
… In this review, the focus is on the role of the carboxyl-terminus of AQP2 as a key
regulatory point for AQP2 trafficking. We provide an overview of AQP2 structure, disease-causing …
regulatory point for AQP2 trafficking. We provide an overview of AQP2 structure, disease-causing …
Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases
ETB Olesen, RA Fenton - Nature Reviews Nephrology, 2021 - nature.com
… Research on the signalling networks and regulatory steps that govern AQP2 trafficking
has … Statins, bosutinib and metformin also regulate aquaporin 2 (AQP2) plasma membrane …
has … Statins, bosutinib and metformin also regulate aquaporin 2 (AQP2) plasma membrane …
Updates and perspectives on aquaporin-2 and water balance disorders
Y Noda, S Sasaki - International journal of molecular sciences, 2021 - mdpi.com
… One of the key factors in the maintenance of body water balance is water reabsorption in the
collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2). AQP2 is a …
collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2). AQP2 is a …
Expression regulation and trafficking of aquaporins
X Zhao, B Liang, C Li, W Wang - Aquaporins, 2023 - Springer
… trafficking allows for rapid and specific AQP regulation in a tissue-dependent manner. The
regulatory … , as the mechanisms controlling the regulation and trafficking of AQP2 have been …
regulatory … , as the mechanisms controlling the regulation and trafficking of AQP2 have been …
Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway
CCS Liu, PW Cheung, A Dinesh… - American Journal …, 2021 - journals.physiology.org
… The trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires
an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we …
an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we …
A multiscale model of the regulation of aquaporin 2 recycling
C Leberecht, M Schroeder, D Labudde - npj Systems Biology and …, 2022 - nature.com
… The transport of aquaporin 2 between membrane and … To understand the regulation of this
system, we aggregated … insight into key regulatory mechanisms of Aquaporin 2 recycling. To …
system, we aggregated … insight into key regulatory mechanisms of Aquaporin 2 recycling. To …
AQP2 trafficking in health and diseases: an updated overview
… AQP2 trafficking and function depend on multiple post-translational modifications. Moreover,
several proteins control different steps activated by the vasopressin stimulation that triggers …
several proteins control different steps activated by the vasopressin stimulation that triggers …
Calcium sensing receptor exerts a negative regulatory action toward vasopressin-induced aquaporin-2 expression and trafficking in renal collecting duct
… in the regulation of AQP2 trafficking and AQP2 protein abundance with a special focus on
the negative feedback of CaSR signaling on AVP-induced AQP2 expression and trafficking in …
the negative feedback of CaSR signaling on AVP-induced AQP2 expression and trafficking in …
Intracellular location of aquaporin-2 serine 269 phosphorylation and dephosphorylation in kidney collecting duct cells
KY Wong, WL Wang, SH Su… - American Journal of …, 2020 - journals.physiology.org
… Rab5 knockdown did not affect vasopressin-induced apical aquaporin-2 (AQP2) trafficking
and S269 phosphorylation. A and B: Rab5 mRNA and protein levels in control (shCon) and …
and S269 phosphorylation. A and B: Rab5 mRNA and protein levels in control (shCon) and …
[HTML][HTML] New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus
… This signaling cascade regulates the water channel protein aquaporin-2 (AQP2). AQP2 is
… This review provides new insights into the transcriptional regulation of the Aqp2 gene in the …
… This review provides new insights into the transcriptional regulation of the Aqp2 gene in the …
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