Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells

Q Yan, Q Wang, J Nan, T Chen, J Wang, Y Zhang… - Theriogenology, 2024 - Elsevier
Heme oxygenase 1 (HO1) is a heat-shock protein family member … the regulatory role of the
PI3K/AKT/mTOR signaling pathway in yak SCs after knocking down and over-expressing HO1…

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

H Khan, A Singh, K Thapa, N Garg, AK Grewal… - Brain Research, 2021 - Elsevier
… targets, other receptors, and pathways that may offer antioxidant, anti-… PI3K pathway in
cerebral ischemic injury in context to nuclear factor erythroid 2–related factor 2 (Nrf2) regulation, …

Regulation of the expression of heme oxygenase-1: Signal transduction, gene promoter activation, and beyond

MV Medina, D Sapochnik, M Garcia Solá… - Antioxidants & Redox …, 2020 - liebertpub.com
… Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by
increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner…

[HTML][HTML] PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

J Shi, J Yu, Y Zhang, L Wu, S Dong, L Wu, L Wu… - Laboratory …, 2019 - Elsevier
… to constitute the assiduous quality control of mitochondria (MQC). Heme oxygenase-1 (HO-1)
protects against sepsis-induced ALI through the modulation of mitochondrial dynamics. …

[HTML][HTML] Targeting the heme oxygenase 1/carbon monoxide pathway to resolve lung hyper-inflammation and restore a regulated immune response in cystic fibrosis

C Di Pietro, HH Öz, TS Murray… - Frontiers in …, 2020 - frontiersin.org
pathways associated with resolution of the inflammatory response, including the heme
oxygenase-1/carbon monoxide (HO-1/CO) pathway. HO-1 is an enzyme that degrades heme

The role of heme oxygenase-1 in remote ischemic and anesthetic organ conditioning

I Bauer, A Raupach - Antioxidants, 2019 - mdpi.com
… RNAs which negatively regulate gene expression at the … While miR-374 expression increased,
the expression of one … conditioning strategies to induce heme oxygenase-1, either on its …

Carbon Monoxide Releasing Molecule‐3 Enhances Heme Oxygenase1 Induction via ROS‐Dependent FoxO1 and Nrf2 in Brain Astrocytes

CC Lin, CC Yang, LD Hsiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
… Salinas et al., “Regulation of heme oxygenase-1 expression through the phosphatidylinositol
3kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant …

Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders

SW Ryter - Antioxidants, 2022 - mdpi.com
… HO-1 may regulate heme bioavailability in these compartments as … -3 (STAT-3),
phosphatidylinositol-3-kinase/Akt (PI3K/Akt), and … HO-1 can also regulate heme bioavailability for …

Enhancement of piperlongumine chemosensitivity by silencing heme oxygenase1 expression in cholangiocarcinoma cell lines

C Talabnin, K Talabnin… - Oncology …, 2020 - spandidos-publications.com
heme oxygenase1 (HO‑1) expression in CCA cell lines. The anti‑proliferative action of PL
in the CCA cell lines KKU‑100 and KKU‑213A was analyzed using … The regulation of redox …

[HTML][HTML] Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: A narrative review

M Wang, J Zhang, N Gong - Annals of palliative medicine, 2022 - apm.amegroups.org
… Therefore, the regulation of PI3K/Akt signaling pathway is expected to become an … pathway
promotes the generation of heme oxygenase-1 (HO-1) by upregulating the expression of Nrf2…