Measurements of airway surface liquid (ASL) on primary airway epithelial cultures (AECs)
grown at air-liquid interface (ALI) identified ASL depletion as a characteristic abnormality in …

… of airway surface liquid mucostasis, chronic inflammation, and eventual respiratory failure. …
are the main determinants of ASL and cellular volume regulation [7, 11]. In CF, deficient or …

… Therefore, the effect of POM-5 on ASL volume regulation was investigated in CF HBEC.
Cells were incubated overnight under oscillatory shear stress that mimics the phasic motion of …

… Airway surface liquid volume regulation. A: diagram of … and 2) shear on airway surfaces due
to phasic airflow (FIGURE 6Ci). … The concentration-dependent shear stress characteristics of …

… The volume of the periciliary layer and mucus hydration is regulated by the transcellular and
… results from mutations in the CFTR gene and leads to cystic fibrosis (CF). More than 90% of …

… control groups. We observed delayed mucociliary transport rate at the cellular level, depletion
of periciliary liquid … the two cohorts were found for airway surface liquid layer depth (ASL), …

… understanding of the airway surface organization by describing … shear stress forces that act
within the surface of airway cells [… mucin production and whose expression is up-regulated in …

… types expressing CFTR (cystic fibrosis [CF] transmembrane … regulator) function disrupts
airway surface liquid (ASL) … airway surface may assure the local control of airway surface …

… Laplace numbers, this second shear stress peak is as severe … the pathogenesis of cystic
fibrosis lung disease. Eur. Respir. … Regulation of depth and composition of airway surface liquid. …

… increased fluid secretion and airway surface liquid height in … designed to mimic the shear
stress associated with tidal … regulation of anion secretion in the human airway epithelium…