Contribution of B cells to cortical damage in multiple sclerosis

P Bhargava, HP Hartung, PA Calabresi - Brain, 2022 - academic.oup.com
… most B cells in parenchymal and meningeal infiltrates from … in ageing mice B cells from the
periphery populated the CNS … the meninges, plaques and CSF and some B-cell clones were …

[HTML][HTML] Breaching brain barriers: B cell migration in multiple sclerosis

C Rodriguez-Mogeda, S Rodríguez-Lorenzo, J Attia… - Biomolecules, 2022 - mdpi.com
… brain parenchyma and the subarachnoid spaces of the meninges, … aggregates, and
parenchyma infiltrates, although many clones … This might create an ideal microenvironment for B

[HTML][HTML] B cells in central nervous system disease: diversity, locations and pathophysiology

RW Jain, VW Yong - Nature Reviews Immunology, 2022 - nature.com
… This is emphasized in multiple sclerosis, in which B cell-… the meningeal B cell aggregates
suggests that B cells are … CNS parenchyma and either directly damage CNS cells or may …

[HTML][HTML] Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis

AL Greenfield, R Dandekar, A Ramesh, EL Eggers… - JCI insight, 2019 - ncbi.nlm.nih.gov
… ), meninges, and CNS parenchyma of MS patients. We sought to investigate the presence
of clonally related B cells … of clonal B cell persistence in CSF and blood, even in patients on …

[HTML][HTML] Selective emergence of antibody-secreting cells in the multiple sclerosis brain

L Bogers, HJ Engelenburg, M Janssen, PPA Unger… - …, 2023 - thelancet.com
… -homing B cells have been identified in multiple sclerosis (MS), … , we freshly obtained
post-mortem blood, CSF, meninges and … T cells invade the brain parenchyma in multiple sclerosis

[HTML][HTML] … between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis

H Touil, R Li, L Zuroff, CS Moore, L Healy… - …, 2023 - thelancet.com
B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS)
patients… IL-10 expressing B cells induce myeloid cell molecules associated with quiescence …

Intrathecal B cells in multiple sclerosis

J Polak - 2024 - duo.uio.no
… can be found in the CSF, meninges, parenchyma, and … in the meninges, where T and B
cells, FDCs, and PBs create compact … We investigate whether the most expanded B-cell clones

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

S Brioschi, WL Wang, V Peng, M Wang, I Shchukina… - Science, 2021 - science.org
… -experienced B cells that populate the meninges in aging … Although no B cells were found
in the brain parenchyma (fig. … that dural B cells had no clonal overlap with circulating B cells in …

[HTML][HTML] Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis

SM Ahmed, NL Fransen, H Touil, I Michailidou… - JCI insight, 2022 - ncbi.nlm.nih.gov
… In summary, while the density of meningeal T and B lymphocytes was not associated with …
(meningeal, parenchymal WM, and cerebrospinal fluid) demonstrated shared B cell clones

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

D Schafflick, J Wolbert, M Heming, C Thomas… - Nature …, 2021 - nature.com
cells) and Ighm (two cells) showed high clonal … -parenchymal lesions 38 . Several studies
have also described the presence of meningeal ectopic lymphoid tissue in multiple sclerosis