[图书][B] Therapeutic Target Identification, Validation and Drug Discovery for Traumatic Brain Injury

A Morin - 2020 - search.proquest.com
… In the current thesis, I used a mouse model of r-mTBI which was … cognition. To address
the heterogenous nature of r-mTBI, I used several cohorts of mice which vary in age at injury (…

[HTML][HTML] Blocking Kv1. 3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice

IK Lai, M Valdearcos, K Morioka, S Saxena… - British journal of …, 2020 - Elsevier
… in preserving postoperative TFC memory in mice with DIO, a … Focusing on the vulnerable
DIO mouse model, we found that … (a) Vehicle control and (b) PAP-1 treated are representative …

The sheep as a large animal model for the investigation and treatment of human disorders

A Banstola, JNJ Reynolds - Biology, 2022 - mdpi.com
… impairment, loss of motor and cognitive functions, and seizures, … studies of remote ischaemic
preconditioning and direct … influence cerebral blood flow following traumatic brain injury has …

A review of plant extracts and plant-derived natural compounds in the prevention/treatment of neonatal hypoxic-ischemic brain injury

H Mohsenpour, M Pesce, A Patruno, A Bahrami… - International journal of …, 2021 - mdpi.com
… in animal models of stroke [255], traumatic brain injury [256], and various kinds of … , preserved
myelination, and minimized the astroglial reactive response. Moreover, long-term cognitive

[HTML][HTML] Ischemic postconditioning attenuates bilateral renal ischemia-induced cognitive impairments

M Tahamtan, A Nazari, I Aghaei… - Basic and Clinical …, 2021 - ncbi.nlm.nih.gov
… of motor coordination and balance. The length of time a given … Remote ischemic conditioning
activates protective pathways … indicated that postconditioning preserved BDNF protein level …

[HTML][HTML] The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury

WB Hubbard, GV Velmurugan, PG Sullivan - Neurochemistry International, 2024 - Elsevier
… Mild mitochondrial uncoupling has proven efficacious in Alzheimer's’ disease (AD) in
preserving short-term memory and enhancing cognition. The repurposing of popular uncouplers, …

[HTML][HTML] Cerebral conditioning: Mechanisms and potential clinical implications

R Sheng, JL Chen, ZH Qin - Brain Hemorrhages, 2022 - Elsevier
… in animal models, researchers explore the clinical application of … Remote ischemic conditioning
is considered the most … preserved the glucocorticoid feedback regulation after hypoxic …

Antioxidant and neuroprotective effects of dexpanthenol in rats induced with traumatic brain injury

PK Bektaşoğlu, T Koyuncuoğlu, D Özaydın… - Injury, 2023 - Elsevier
Trauma-induced primary damage is followed by secondary damage, exacerbating traumatic
brain injury … tissues against oxidative damage in various inflammation models. This study …

[HTML][HTML] … the mutual promotion of inflammation and oxidative stress mitigates cognitive decline and depression-like behavior in rmTBI mice by promoting myelin …

S Lu, QQ Ge, MS Yang, Y Zhuang, X Xu, F Niu… - Biomedicine & …, 2024 - Elsevier
… in patients with severe traumatic brain injury. However, … that can be easily prepared and
preserved, and water is the only product … In this study, the animal model was identified through …

Comparative study of brain damage and oxidative stress using two animal models of the shaken baby syndrome

S del Ángel Daniel, LR Norma, OB Norma… - Experimental …, 2022 - Elsevier
… ” and other forms of traumatic brain injury inflicted. A recent … The number of neuronal cells,
whether preserved or … normal brain function, including learning, memory and cognition. …