… von Hippel-Lindau (VHL) disease. This autosomal dominant … The diseased VHL kidney is
characterized by renal cysts and … as VHL gene-inactivated pancreatic cysts; most cysts were of …

… with functional inactivation of the Von Hippel– Lindau protein … A mouse model that conditionally
inactivated VHL in … cell carcinomas (P=0.0001), renal cysts (P=0.027), and pancreatic …

… of the VHL tumor suppressor gene cause von Hippel–Lindau … VHL families are said to have
type 1 disease if they display a … VHL inactivation causes renal cysts in mice and humans, but …

… with a clinical diagnosis of Von Hippel–Lindau (VHL) disease … The VHL gene is inactivated
in both VHL disease-associated … Renal cysts may present radiographically as simple cysts …

… inactivation occurring in most clear cell RCC and in tumours … in multiple renal cysts and
tumours (similar to kidneys in VHL … The von Hippel-Lindau tumor-suppressor gene product forms …

… development and progression of DKD and shall be clarified in our study. PT-von-Hippel-Lindau
(Vhl)-deleted mouse … To study if changes in the PT in addition to glomerular structures …

… kidney cystic disease [3]. Moreover, genetic risk factors are involved in the pathogenesis of
RCC including the von Hippel–Lindau … generate ccRCC in mouse kidneys by inactivating Vhl. …

… of wild-type von Hippel-Lindau renal cell carcinoma with clear cell … The biallelic inactivation
of VHL can result from the … as identified in the tumour to determine if both events are …

von Hippel-Lindau (VHL) disease is a rare hereditary cancer syndrome that causes a
predisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and …

… The von Hippel-Lindau tumor suppressor gene (VHL) is … The HIF signaling pathway is most
frequently activated by inactivating … Benign renal cysts and malignant RCC are present in two-…