[HTML][HTML] Naringenin ameliorates renovascular hypertensive renal damage by normalizing the balance of renin-angiotensin system components in rats

Z Wang, S Wang, J Zhao, C Yu, Y Hu, Y Tu… - … Journal of Medical …, 2019 - ncbi.nlm.nih.gov
… system (RAS) is known to play an important role. … upregulated in both the cortex and medulla
of the nonclipped kidney. This … the ability of suppressing local ACE level in kidney as what …

The pivotal role of melatonin in ameliorating chronic kidney disease by suppression of the reninangiotensin system in the kidney

N Ohashi, S Ishigaki, S Isobe - Hypertension Research, 2019 - nature.com
reninangiotensin system (RAS) is one of the most importantBoth angiotensin and
melatonin may interact to regulate … ameliorates intrarenal RAS activation and renal injury (Fig. 6)…

Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis

A Al‐Kadi, M El‐Daly, NFG El‐Tahawy… - Fundamental & …, 2022 - Wiley Online Library
… of the renin angiotensin aldosterone system (RAAS) inhibition on … aldosterone system (RAAS)
plays an important function to … This study involved two separate arms: mechanistic and …

Egr1 knockdown combined with an ACE inhibitor ameliorates diabetic kidney disease in mice: blockade of compensatory renin increase

F Hu, R Xue, X Wei, Z Wang, S Luo, J Lin… - Diabetes, Metabolic …, 2020 - Taylor & Francis
… whether inhibition of Egr1 can suppress compensatory renin … Egr1 was an important
transcriptional factor in the progress of … renin feedback and alleviate renal injury. In addition, …

Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome

Y Li, L Kang, K Rong, Y Zhang, Y Suo, M Yuan, Q Bao… - Life Sciences, 2021 - Elsevier
… of the renin-angiotensin system (RAS) of both the heart and … These changes were ameliorated
by LCZ696 and valsartan … slowing the progression of renal injury using a mouse model of …

Silencing of Central (Pro) renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease

J Li, M Liang, T Zeng, M Qiu, M Zhang… - Antioxidants & Redox …, 2021 - liebertpub.com
… known to play important roles during many physiological and … as well as angiotensin converting
enzyme 1–angiotensin II–… of U0126 could only suppress the activation of MAPK/ERK1/2. …

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy

V Malek, N Sharma, H Sankrityayan, AB Gaikwad - Life Sciences, 2019 - Elsevier
… common causes of the end-stage renal failure, globally [[1], [2], … One of the notable findings
of the present study is that the … and tubulointerstitial fibrosis and suppressed inflammatory, …

[HTML][HTML] Fiend and friend in the renin angiotensin system: an insight on acute kidney injury

N Sharma, HJ Anders, AB Gaikwad - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… insults induced renal injury to CKD by suppressing different … AKI to CKD transition via
ameliorating early renal blood flow … of the AT1R has a prominent role in the pathogenesis of AKI …

Angiotensin–neprilysin inhibition confers renoprotection in rats with diabetes and hypertension by limiting podocyte injury

E Uijl, DC't Hart, LCW Roksnoer… - Journal of …, 2020 - journals.lww.com
… Pharmacological inhibition of the renin--angiotensin--… , this could also prevent renal damage
mediated by inflammatory … with sacubitril/valsartan ameliorated chronic renal ischemia and …

Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice

KN Miyata, CS Lo, S Zhao, MC Liao, Y Pang… - Clinical …, 2021 - portlandpress.com
… the role of the intrarenal reninangiotensin system (RAS) on … can ameliorate Ang II-induced
hypertensive renal injury in mice… important regulator of SGLT2 expression in human kidneys. …