… protects against renal damage in renin‐angiotensin system–… another FXa inhibitor, edoxaban,
suppressed the accumulation … study might provide an important clinical implication on the …

… of renal impairment [4]. Since renin–angiotensin system (RAS) inhibitors are thought to have
… rats, a clear amelioration of existing renal injury by esaxerenone was observed without SBP …

… Angiotensin II (Ang II), the main effector of the renin–… , suggesting an important role for IL-1β
during the progression of … , the suppression of IL-1β ameliorated Ang II-induced renal injury. …

… inhibition of ACE2 increases renal injury [35]. Harris et al. [37], reported an increase in
ACE/ACE2 ratio in both … It is important to note that we lack sufficient clinical data to support above …

… Abnormal renin-angiotensin system (RAS) activation plays a critical role … It is well known that
the renin-angiotensin system (RAS), … Inhibition of AT1R and AT2R suppresses renal tubular …

… and renal injury … suppression of RAS activation within the central nervous system, the
attenuation of Ang II–stimulated aldosterone release from the adrenal glands, and the amelioration …

… in both the kidney and … damage induced by renal I/R was evident from increased mRNA
expression of vimentin (Fig. 2), one of the most important molecular markers of renal damage [45]…

… highlights recent efforts to target RAAS to ameliorate fibrosis. … inhibition leads to Ang II-dependent
oxidative renal damage … reported to be effective in suppressing hepatic fibrosis [150,…

… of renal damage [7–10]. Among the diverse mediators that take part in AKI induced by RIRI,
the renin-angiotensin system (RAS) plays an important … the removal of a peptide from the C-…

… for the prevention of renal injury in Ang II-… an important risk factor for the progression of
renal and cardiovascular disease [6, 7]. The direct renin inhibitor (DRI), aliskiren, by suppressing …