α2A-Adrenoceptors modulate renal sympathetic neurotransmission and protect against hypertensive kidney disease

L Hering, M Rahman, H Hoch, L Markó… - Journal of the …, 2020 - journals.lww.com
renin-angiotensin system, such as hypertensive kidney … and hypertensive kidney disease,
we induced angiotensin II (AngII)… and NKCC2 was significantly suppressed in both α2A-AR-KO …

Novel roles of the renal angiotensin-converting enzyme

JF Giani, LC Veiras, JZY Shen, EA Bernstein… - Molecular and cellular …, 2021 - Elsevier
… the renin angiotensin system (RAS) are expressed in the kidneyusing a model of salt
sensitivity induced by renal injury … therapy for amelioration of albuminuria and renal disease …

Canagliflozin prevents intrarenal angiotensinogen augmentation and mitigates kidney injury and hypertension in mouse model of type 2 diabetes mellitus

TC Woods, R Satou, K Miyata, A Katsurada… - American journal of …, 2019 - karger.com
… AGT augmentation and ameliorates kidney injury and … leading to decreased intrarenal
angiotensin II production thus causing decreases in blood pressure and diminished renal injury in …

Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2/STAT pathway

L He, J Du, Y Chen, C Liu, M Zhou… - American Journal …, 2019 - journals.physiology.org
renin developed much more severe colitis, leading to high mortality (50), whereas blockade
of the RAS with AT1R blocker or ACE inhibitor ameliorated … effective in suppressing colonic …

[HTML][HTML] Anti-oxidant impact of Lisinopril and Enalapril against acute kidney injury induced by doxorubicin in male Wistar rats: Involvement of kidney injury molecule-1

GF Asaad, A Hassan, RE Mostafa - Heliyon, 2021 - cell.com
… with ACE inhibitors to ameliorate the induced acute kidney injury (… examine the role of two
non-sulfhydryl ACE inhibitors; viz., … TAC into normal levels determining a prominent antioxidant …

[HTML][HTML] Autophagy in metabolic syndrome: breaking the wheel by targeting the reninangiotensin system

KR Menikdiwela, L Ramalingam, F Rasha… - Cell Death & …, 2020 - nature.com
Both in vivo and in vitro results confirm that autophagy … suppression will ultimately induce
insulin resistance during MetS… ingestion and angiotensin II (Ang II) are important contributors to …

[HTML][HTML] ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury

C Xu, F Wang, Y Chen, S Xie, D Sng… - … Physiology-Renal …, 2020 - journals.physiology.org
… Additionally, both apelin and ELA protect against pressure … not only significantly
suppressed inflammatory molecules (IL-1β… Hypertensive Dahl SS rat is a well-known low-systemic-renin

Inhibition of MyD88 attenuates angiotensin II-induced hypertensive kidney disease via regulating renal inflammation

K Lin, W Luo, N Yang, L Su, H Zhou, X Hu… - International …, 2022 - Elsevier
… Although the risk of serious renal injury in hypertensive patients is … The renin-angiotensin-aldosterone
system (RAAS) plays an … MyD88 inhibitor LM8 suppresses Ang II-induced …

Reninangiotensin–aldosterone system inhibitors and risk of Covid-19

HR Reynolds, S Adhikari, C Pulgarin… - … England Journal of …, 2020 - Mass Medical Soc
… the reninangiotensin–aldosterone system (RAAS) and its neurohormonal pathways; treatment
with RAAS inhibitors … that treatment with ACE inhibitors or angiotensin-receptor blockers (…

The Controversy of ReninAngiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection

AS Manolis, TA Manolis, AA Manolis… - Journal of …, 2020 - journals.lww.com
… One can deduce from this important information that there … cytokines; it can ameliorate lung
histopathology and promote … heart disease, thus suppressing unfavorable remodeling of the …