Angiotensin-[1–7] attenuates kidney injury in experimental Alport syndrome

HS Choi, IJ Kim, CS Kim, SK Ma, JW Scholey… - Scientific Reports, 2020 - nature.com
… the actions of the renin-angiotensin-system via the Mas … effectively suppress the progression
of kidney diseases in both … Ang-[1–7] could ameliorate the renal injury in Col4a3 −/− mice as …

Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats

J Gong, M Luo, Y Yong, S Zhong, P Li - Cell Death Discovery, 2022 - nature.com
… Alamandine (Ala) is a novel member of the reninangiotensin-… , thereby suppressing the
apoptosis in renal tubular cells. … Ala ameliorates NaCl-induced apoptosis of the renal tubular …

Effects of dapagliflozin on renin-angiotensin-aldosterone system under renin-angiotensin system inhibitor administration

M Isshiki, I Sakuma, Y Hayashino, T Sumita… - Endocrine …, 2020 - jstage.jst.go.jp
… PRA and PAC are usually suppressed by a high salt intake, … are all the more clinically
important. However, how SGLT2Is … ) reportedly ameliorate the course of heart failure (RALES [13…

Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia

R Ali, S Patel, T Hussain - … Journal of Physiology-Renal …, 2021 - journals.physiology.org
… cells and onset of renal injury during IR and modulates Tregs … AT 2 R agonist treatment at
2 h clearly suppressed leukocytes, … Our findings give initial account of how renin, angiotensin

Repositioning of Ticagrelor: Renoprotection mediated by modulating renin-angiotensin system, inflammation, autophagy and galectin-3

SM Mansour, SA Abd El-Aal, HS El-Abhar… - European Journal of …, 2022 - Elsevier
important cascades that modulate kidney function is the renin… the I/R-induced renal injury
via augmenting the Epac-1/Rap-1 … I/R injury upregulated the renal gene expression of the two

… with the inhibition of renal artery AT1R/ET-1/iNOS axis in a rat model of diabetic nephropathy with suppression of inflammation and oxidative stress and kidney injury

AF Dawood, A Maarouf, NM Alzamil, MA Momenah… - Biomedicines, 2022 - mdpi.com
… and irreversible renal failure. The maladaptive activation of the reninangiotensin system
(… is also able to ameliorate renal artery AT1R/ET-1 axis–mediated kidney injury to the same …

Dysregulation of the renin-angiotensin system in septic shock: mechanistic insights and application of angiotensin II in clinical management

F Senatore, P Balakumar, G Jagadeesh - Pharmacological research, 2021 - Elsevier
leading to accelerated RAS-associated tissue injury [40]. … Both NO and cytokines are capable
of suppressing both AT-… AT-1 receptor genes are regulated both by NO and by cytokines [5]…

Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice

J Zhang, Q Xu, F Ren, Y Liu, R Cai… - Canadian Journal of …, 2021 - cdnsciencepub.com
… pathway has an important role in Ang II–induced renal injury. … inhibition of YAP activation
by verteporfin suppresses renal … of hypertensive renal disease, in particular some renin-…

Angiotensin 1 receptor antagonist attenuates acute kidney injury-induced cognitive impairment and synaptic plasticity via modulating hippocampal oxidative stress

F Sharifi, P Reisi, M Malek - Life sciences, 2019 - Elsevier
renal damage on memory and cognitive functions of the hippocampus have not yet been
studied. Activation of renin-angiotensin … Losartan has also been shown to ameliorate alterations …

Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System: JACC Review Topic of the Week

A Brojakowska, J Narula, R Shimony… - Journal of the American …, 2020 - jacc.org
important counter regulatory mechanism to the classic RAS. … suppressed upregulation of
ACE2 mRNA, which suggested … and inflammatory injury; however, this was ameliorated by the …