Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior
… We analyzed publicly available transcriptome datasets of the … dopamine release in mPFC
mediates behavioral learning … -related core gene reprogramming takes place in the same cell …
mediates behavioral learning … -related core gene reprogramming takes place in the same cell …
Microglia control escalation of drinking in alcohol-dependent mice: genomic and synaptic drivers
… mPFC transcriptome is altered in response to MG depletion and alcohol dependence. (A)
Volcano plot showing log 2 fold change against log10 p value for the main effect of MG …
Volcano plot showing log 2 fold change against log10 p value for the main effect of MG …
Alcohol and the brain: from genes to circuits
G Egervari, CA Siciliano, EL Whiteley, D Ron - Trends in neurosciences, 2021 - cell.com
… can drive the development and maintenance of alcohol use disorder (AUD). We provide an
update on … For example, increased enrichment of DNA methylation in the mPFC was linked to …
update on … For example, increased enrichment of DNA methylation in the mPFC was linked to …
[HTML][HTML] Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence
NA Salem, L Manzano, MW Keist, O Ponomareva… - Neurobiology of …, 2024 - Elsevier
… spatial transcriptomics data to deconvolute the information of overlapping cells in spatial
transcriptomics … changes in the mPFC of a mouse model of alcohol dependence and identify …
transcriptomics … changes in the mPFC of a mouse model of alcohol dependence and identify …
Transcriptome analysis of alcohol drinking in non-dependent and dependent mice following repeated cycles of forced swim stress exposure
SP Farris, GR Tiwari, O Ponomareva, MF Lopez… - Brain sciences, 2020 - mdpi.com
… in gene expression across the medial prefrontal cortex (CTX), … reprogramming of cellular
responses is a latent feature of … of chronic stress and alcohol dependence, our current studies …
responses is a latent feature of … of chronic stress and alcohol dependence, our current studies …
Non-coding RNA in alcohol use disorder by affecting synaptic plasticity
S Zhu, J Wu, J Hu - Experimental brain research, 2022 - Springer
… We also found that injecting BDNF into the medial PFC (mPFC) of alcohol-dependent rats
reduced alcohol self-administration to a certain extent, but injecting BDNF into the ventral …
reduced alcohol self-administration to a certain extent, but injecting BDNF into the ventral …
Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects …
… and alcohol use disorder (AUD). Here, we tested the hypothesis that medial prefrontal cortex
CRF1-expressing (mPFC … , we sequenced the transcriptome of mPFC CRF1+ neurons and …
CRF1-expressing (mPFC … , we sequenced the transcriptome of mPFC CRF1+ neurons and …
Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene …
FW Lohoff, A Roy, J Jung, M Longley, DB Rosoff… - Molecular …, 2021 - nature.com
… In addition, the mechanisms by which alcohol leads to widespread epigenetic
reprogramming are not addressed by our study. One possibility is that epigenetic change is the …
reprogramming are not addressed by our study. One possibility is that epigenetic change is the …
A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder
MM Friske, EC Torrico, MJW Haas, AM Borruto… - bioRxiv, 2022 - biorxiv.org
… We performed a meta-analysis on transcriptome-wide datasets derived from … of alcohol
dependence and AUD in a comprehensive manner. (i) Meta-analysis in post-dependent rodent …
dependence and AUD in a comprehensive manner. (i) Meta-analysis in post-dependent rodent …
[PDF][PDF] A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder–a Translational Approach
MM Friske, EC Torrico, AM Borruto, MJ Haas… - 2022 - researchgate.net
… transcriptome-wide datasets derived from postdependent rodent and post-mortem human
brain tissue in the context of alcohol dependence … (i) Meta-analysis in post-dependent rodent …
brain tissue in the context of alcohol dependence … (i) Meta-analysis in post-dependent rodent …