[HTML][HTML] Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
… activity of the indirect pathway and impaired motor control, particularly hypokinesia. … Since
locomotor abnormalities in D 2 R knockout mice were rescued by the blockade of A 2A R, not …
locomotor abnormalities in D 2 R knockout mice were rescued by the blockade of A 2A R, not …
[HTML][HTML] How do adenosine A2A receptors regulate motor function?
A Mori - Parkinsonism & related disorders, 2020 - Elsevier
… while A 2A antagonists improve motor function in dopamine D2 hyphenate receptor-deficient
(D2KO) mice [62,63], demonstrating independence of A 2A receptors from D2 receptors …
(D2KO) mice [62,63], demonstrating independence of A 2A receptors from D2 receptors …
PET Imaging of the Interaction between Adenosine A2A and Dopamine D2 Receptors in Animal Models of Brain Diseases
K Prasad - 2023 - research.rug.nl
… Since locomotor abnormalities in D2R knockout mice were rescued by the blockade of A2AR,
… as schizophrenia and A2A signaling in neurodegenerative disorders such as Parkinson’s …
… as schizophrenia and A2A signaling in neurodegenerative disorders such as Parkinson’s …
Dopamine D2L receptor deficiency causes stress vulnerability through 5-HT1A receptor dysfunction in serotonergic neurons
N Shioda, Y Imai, Y Yabuki, W Sugimoto… - Journal of …, 2019 - Soc Neuroscience
… SIGNIFICANCE STATEMENT Etiologies of mental disorders … First, we analyzed the locomotor
activity in the open-field test. In … in D 2L R-KO mice was significantly rescued in AAV-Pet1/D …
activity in the open-field test. In … in D 2L R-KO mice was significantly rescued in AAV-Pet1/D …
[HTML][HTML] Dopaminergic modulation of forced running performance in adolescent rats: role of striatal D1 and extra-striatal D2 dopamine receptors
… the role of dopamine receptors in mediating the locomotor … behavior in the open field, although
a robust motor impairment … locomotor activity in the open field are dopamine dependent. …
a robust motor impairment … locomotor activity in the open field are dopamine dependent. …
Istradefylline – a first generation adenosine A2A antagonist for the treatment of Parkinson's disease
P Jenner, A Mori, SD Aradi… - Expert Review of …, 2021 - Taylor & Francis
… affect motor function in dopamine D2 receptor-deficient mice, … in locomotor motor activity and
reversal of motor disability with no … Indeed, while the initial development and adoption of the …
reversal of motor disability with no … Indeed, while the initial development and adoption of the …
[HTML][HTML] Activation of dopamine D2 receptors attenuates neuroinflammation and ameliorates the memory impairment induced by rapid eye movement sleep …
P Ugalde-Muñiz, MG Hernández-Luna… - Frontiers in …, 2022 - frontiersin.org
… to establish the frontier between locomotor and cognitive impairments in these models.
Based on our results, it seems plausible that D2DR-dependent memory rescue depends on an …
Based on our results, it seems plausible that D2DR-dependent memory rescue depends on an …
The adenosine A2A receptor in the basal ganglia: Expression, heteromerization, functional selectivity and signalling
… The A 2A R can interact with other receptors as adenosine A 1 , dopamine D 2 , or … The
motor impairment in animals that are knockout for the D 2 receptor are rescued by A 2A R …
motor impairment in animals that are knockout for the D 2 receptor are rescued by A 2A R …
Istradefylline for Treating Parkinson's Disease
T Kanda, M Nomoto - NeuroPsychopharmacotherapy, 2020 - Springer
… Also, we will summarize the potential feature aspects of the adenosine A2A receptor …
Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A …
Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A …
Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders
A Annamneedi, C Gora, A Dudas… - British journal of …, 2023 - Wiley Online Library
… KO mice show impaired reward processing and locomotion. … cell lines, which is either
rescued by deletion of its long N… The adenosine A2A receptor agonist, CGS 21680, attenuates …
rescued by deletion of its long N… The adenosine A2A receptor agonist, CGS 21680, attenuates …