… rare neuro-metabolic disorder Rett syndrome (RTT) is discussed as a prototype for precision
medicine, demonstrating how mouse models … reversal may be possible in human patients. …

… to female MeCP2+/− mice. This mouse model fully recapitulates symptoms of Rett syndrome
and is widely used in the literature to study the mechanisms underlying this disease.In …

… cause Rett syndrome, a progressive neurological disorder in … At present there are no effective
treatments for Rett syndrome, … Here we find, using a mouse model of Rett syndrome, that …

… expression and/or TrkB activation in Mecp2-deficient mouse models of RTT can ameliorate
or reverse abnormal neurological phenotypes that mimic human RTT symptoms. The present …

… Promisingly, supplementation of choline, a common dietary micronutrient, to various mouse
models of RTT markedly improved their motoric function [18, 19]. But, the exact mechanism …

… Rett syndrome (RTT) is a neurodevelopmental disorder … , we created and characterized a
mouse model with the common p.… Mecp2 R294X mice exhibit phenotypic abnormalities similar …

… Tubastatin A treatment on reversing early RTT-related abnormalities was therefore investigated
in a Mecp2 308/y mouse model. In this preclinical study, we identified in mice a safe and …

… This work has been greatly enhanced by the availability of mouse models of Rett syndrome.
… primary defect in Rett syndrome, raises the key question of lower age limit for major reversal …

… that CNF1 administration also rescues the neurobehavioural abnormalities in a mouse
model of Alzheimer’s disease, another disorder characterised by cognitive dysfunction [16]. …

… sumo-mutant mice. Here, we examined the role of Wnt6 in MeCP2 T158A mouse model of
RTT. … locomotor impairment and social behavioral deficits in these animals. MeCP2 T158A …