Human immunology and immunotherapy: main achievements and challenges
J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
… this review is ILCs. ILC1s are dependent on the T-box transcription factor T-bet and produce
interferon gamma (… a more persistent effect than is endowed by trained immunity 81,94,95 . …
interferon gamma (… a more persistent effect than is endowed by trained immunity 81,94,95 . …
[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
… to improve the safety and effectiveness of cytokine immunotherapy. In this review we
highlight recent advances in cytokine biology and engineering for cancer immunotherapy. …
highlight recent advances in cytokine biology and engineering for cancer immunotherapy. …
Interferons α and β in cancer: therapeutic opportunities from new insights
EC Borden - Nature Reviews Drug Discovery, 2019 - nature.com
… aspects of the interferon axis (production and action) and … or immunotherapeutics (Box 1).
Because DCA and AZA have not been associated with interferon-like side effects, interferons …
Because DCA and AZA have not been associated with interferon-like side effects, interferons …
Next-generation cytokines for cancer immunotherapy
… effects as monotherapy or combination therapy for both preclinical and clinical applications
will be discussed in this review. … + T cells while impairing cytokine production from NK cells in …
will be discussed in this review. … + T cells while impairing cytokine production from NK cells in …
Targeting interferon-γ in hyperinflammation: opportunities and challenges
F De Benedetti, G Prencipe, C Bracaglia… - Nature Reviews …, 2021 - nature.com
… ) or of increased type I interferon production and signalling in … or immune interferon) is a
cytokine with multiple effects on … of T cell-engaging immunotherapeutic agents (such as chimeric …
cytokine with multiple effects on … of T cell-engaging immunotherapeutic agents (such as chimeric …
The interferon-gamma paradox in cancer
MR Zaidi - Journal of interferon & cytokine research, 2019 - liebertpub.com
… phases through its regulatory effects on immunoevasive functions … explosion of anticancer
immunotherapeutic strategies in the clinic… Here, the current state of this dichotomy is reviewed. …
immunotherapeutic strategies in the clinic… Here, the current state of this dichotomy is reviewed. …
Interferon γ and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity
E Alspach, DM Lussier… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
… This review focuses on the diverse positive and negative … However, aberrant production
of IFN-γ has been associated with … these effects to improve cancer immunotherapy efficacy. …
of IFN-γ has been associated with … these effects to improve cancer immunotherapy efficacy. …
[HTML][HTML] … of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent …
H Ding, G Wang, Z Yu, H Sun, L Wang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… This review assessed IFNγR polymorphisms, expression and … are insensitive to the
antiproliferative effects of the IFN-γ/STAT1 … of the IFNγR signaling suppressed production of IFN-γ …
antiproliferative effects of the IFN-γ/STAT1 … of the IFNγR signaling suppressed production of IFN-γ …
… -immunotherapy medicine interferon-γ (4 CH) displays similar immunostimulatory and immunomodulatory effects than those of biologically active human interferon-γ …
C Jacques, M Chatelais, K Fekir, A Brulefert… - International Journal of …, 2022 - mdpi.com
… available recombinant human IFN-γ used … human PBMCs, IFN-γ treatment does not directly
induce p40 gene expression and protein production, but it primes monocytic cells to produce …
induce p40 gene expression and protein production, but it primes monocytic cells to produce …
Cytokines in clinical cancer immunotherapy
P Berraondo, MF Sanmamed, MC Ochoa… - British journal of …, 2019 - nature.com
… In this review, we provide an overview of the novel trends in … antiangiogenic effects are
mediated by the production of IFN-… to have a detrimental effect on immunotherapies based on the …
mediated by the production of IFN-… to have a detrimental effect on immunotherapies based on the …