Mechanistic insights into genetic susceptibility to prostate cancer
P Tian, M Zhong, GH Wei - Cancer Letters, 2021 - Elsevier
… loop to block the promoter-enhancer interaction and the … levels of CEACAM21 and the long
noncoding RNA PCAT19 [45,48]. … of mechanisms of SNP-mediated transcription factor DNA-…
noncoding RNA PCAT19 [45,48]. … of mechanisms of SNP-mediated transcription factor DNA-…
Long non-coding RNAs at the chromosomal risk loci identified by prostate and breast cancer GWAS
P Janaththani, SL Srinivasan, J Batra - Genes, 2021 - mdpi.com
… the lncRNA genes, including a new prostate cancer risk-… a promoter-to-enhancer switching
mechanism [63]. The … PCAT19-long promoted prostate cancer progression by interacting with …
mechanism [63]. The … PCAT19-long promoted prostate cancer progression by interacting with …
Variations in genomic regions encoding long non-coding RNA genes associated with increased prostate cancer risk
E Bozgeyik - Mutation Research/Reviews in Mutation Research, 2023 - Elsevier
… The T-risk allele of SNP rs887391 in the PCAT19 gene was … In addition, the T risk allele
of rs887391, similar to … the PCAT19 long isoform through promoter-enhancer switching by …
of rs887391, similar to … the PCAT19 long isoform through promoter-enhancer switching by …
[HTML][HTML] The evolution of long noncoding RNA acceptance in prostate cancer initiation, progression, and its clinical utility in disease management
VR Ramnarine, M Kobelev, EA Gibb, M Nouri, D Lin… - European urology, 2019 - Elsevier
… lncRNAs harbouring SNPs associated with the risk of … PCAT19 has two isoforms, PCAT19
short and long. The … that drive CRPC [49]. Therapeutically, this could be a targetable …
short and long. The … that drive CRPC [49]. Therapeutically, this could be a targetable …
Non-coding variants in cancer: mechanistic insights and clinical potential for personalized medicine
M Lange, R Begolli, A Giakountis - Non-coding RNA, 2021 - mdpi.com
… regulates expression of PCAT19 in prostate cancer through enhancer–… of PCAT19-long
isoform through a promoter–enhancer … Subsequently, the miR-204-SNP mediated loss of FZD4 …
isoform through a promoter–enhancer … Subsequently, the miR-204-SNP mediated loss of FZD4 …
Significance of single-nucleotide variants in long intergenic non-protein coding RNAs
H Zou, LX Wu, L Tan, FF Shang… - … in Cell and Developmental …, 2020 - frontiersin.org
… In nasopharyngeal carcinoma (NPC), lncRNA GAS5 variant … Recent studies have reported
that prostate cancer risk-… abundance of PCAT19-long through promoter-enhancer switching. …
that prostate cancer risk-… abundance of PCAT19-long through promoter-enhancer switching. …
Systematic fine-mapping and functional studies of prostate cancer risk variants
Y Qian, J Wang, B Wang, W Wang, P Li, Z Zhao… - Iscience, 2023 - cell.com
… over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants
remain elusive. Identification of causal variants and their targets from … from prostate-specific …
remain elusive. Identification of causal variants and their targets from … from prostate-specific …
Functional polymorphisms of the lncRNA H19 promoter region contribute to the cancer risk and clinical outcomes in advanced colorectal cancer
W Qin, X Wang, Y Wang, Y Li, Q Chen, X Hu… - Cancer Cell …, 2019 - Springer
… , lncRNAs are the key players with multiple functions in carcinogenesis including regulating
cancer cell cycle, proliferation, and apoptosis through … effect of risk genotypes on cancer risk, …
cancer cell cycle, proliferation, and apoptosis through … effect of risk genotypes on cancer risk, …
Long non-coding RNAs in prostate cancer: Biological and clinical implications
… In this review, we summarise the biology of lncRNAs and their mechanisms … risk for both
developing and dying from PCa, maps to the PCAT19 and mediates a switch of expression from …
developing and dying from PCa, maps to the PCAT19 and mediates a switch of expression from …
[HTML][HTML] Unravelling the role of long non-coding RNAs in prostate carcinoma
P Anil, SG Dastidar, S Banerjee - Advances in Cancer Biology-Metastasis, 2022 - Elsevier
… functional role of lncRNAs in PCa management over the past two … PCAT19 is influenced
by the presence or lack of a PCa risk … adjustment drives oncogenic development and prostate …
by the presence or lack of a PCa risk … adjustment drives oncogenic development and prostate …