… loop to block the promoter-enhancer interaction and the … levels of CEACAM21 and the long
noncoding RNA PCAT19 [45,48]. … of mechanisms of SNP-mediated transcription factor DNA-…

… the lncRNA genes, including a new prostate cancer risk-… a promoter-to-enhancer switching
mechanism [63]. The … PCAT19-long promoted prostate cancer progression by interacting with …

… The T-risk allele of SNP rs887391 in the PCAT19 gene was … In addition, the T risk allele
of rs887391, similar to … the PCAT19 long isoform through promoter-enhancer switching by …

… lncRNAs harbouring SNPs associated with the risk of … PCAT19 has two isoforms, PCAT19
short and long. The … that drive CRPC [49]. Therapeutically, this could be a targetable …

… regulates expression of PCAT19 in prostate cancer through enhancer–… of PCAT19-long
isoform through a promoter–enhancer … Subsequently, the miR-204-SNP mediated loss of FZD4 …

… In nasopharyngeal carcinoma (NPC), lncRNA GAS5 variant … Recent studies have reported
that prostate cancer risk-… abundance of PCAT19-long through promoter-enhancer switching. …

… over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants
remain elusive. Identification of causal variants and their targets from … from prostate-specific …

… , lncRNAs are the key players with multiple functions in carcinogenesis including regulating
cancer cell cycle, proliferation, and apoptosis through … effect of risk genotypes on cancer risk, …

… In this review, we summarise the biology of lncRNAs and their mechanisms … risk for both
developing and dying from PCa, maps to the PCAT19 and mediates a switch of expression from …

… functional role of lncRNAs in PCa management over the past two … PCAT19 is influenced
by the presence or lack of a PCa risk … adjustment drives oncogenic development and prostate …