Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS

S Bodkhe, M Nikam, AP Sherje, T Khan… - International …, 2020 - Elsevier
Roflumilast, a promising therapeutic approach in inflammatory airway … roflumilast in COPD
and asthma. However, there is no published clinical evidence to date for the role of roflumilast

An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma

D Al-Sajee, X Yin, GM Gauvreau - Expert opinion on …, 2019 - Taylor & Francis
… and related findings in chronic obstructive pulmonary disease (COPD). The … drugs such
as roflumilast have an excellent safety profile and efficacy in patients with asthma and COPD. …

The role of the pharmacist in optimizing outcomes with roflumilast, a PDE4 inhibitor for the treatment of COPD

D Williams - Journal of Pharmacy Practice, 2022 - journals.sagepub.com
treatment discontinuation resulting from the use of an uptitration regimen in patients with …
COPD who initiate therapy with roflumilast. Pharmacists have a central role in effective COPD

Tanimilast, a novel inhaled PDE4 inhibitor for the treatment of asthma and chronic obstructive pulmonary disease

F Facchinetti, M Civelli, D Singh, A Papi… - Frontiers in …, 2021 - frontiersin.org
… The results of this study were consistent with those obtained with roflumilast in asthma patients
where a significant attenuation of LAR and other mediators was also observed (Bardin et …

[HTML][HTML] Effects of Roflumilast on Patients with Chronic Obstructive Pulmonary Disease Treated with Inhaled Corticosteroid/Long-Acting β2 Agonist: A Meta-analysis

S Zeng, H Bai, M Zou - … and Mathematical Methods in Medicine, 2022 - hindawi.com
… This study evaluated the efficacy and safety of roflumilast in patients with moderate to severe
COPD using RCT data in combination with inhaled ICS/LABA. The results suggested that …

[HTML][HTML] Phosphodiesterase-4 inhibitors for non-COPD respiratory diseases

T Kawamatawong - Frontiers in pharmacology, 2021 - frontiersin.org
… This article will discuss the evidence of roflumilast and other PDE4 inhibitors for treating
roflumilast to COPD standard treatment. The evidence of roflumilast in the treatment of COPD

Novel therapeutic targets and drug development for the precision treatment of COPD

S Assaf, NA Hanania - … Review of Precision Medicine and Drug …, 2019 - Taylor & Francis
roflumilast across all age groups, smoking status and geographic regions [Citation26]. A
Cochrane database systematic revealed that roflumilast … add-on benefit of roflumilast to patients …

Clinical relevance of the anti-inflammatory effects of roflumilast on human bronchus: potentiation by a long-acting beta-2-agonist

H Salvator, A Buenestado, M Brollo, E Naline… - Frontiers in …, 2020 - frontiersin.org
… Background: Roflumilast is an option for treating patients with severe COPD and frequent …
(PDE) 4 inhibitor roflumilast and its active metabolite roflumilast N-oxide affect the release of …

Roflumilast: A Review of Chronic Obstructive Pulmonary Disease (COPD) Treatment

I Octafia, DO Sari, N Wulandari, S Annisa… - Qanun …, 2021 - repository.ubaya.ac.id
… The efficacy of Roflumilast can prevent exacerbations of … Roflumilast is better than the group
without additional. This paper aimed to review systematically Roflumilast as COPD treatment

[HTML][HTML] Phosphodiesterases as therapeutic targets for respiratory diseases

H Zuo, I Cattani-Cavalieri, N Musheshe… - Pharmacology & …, 2019 - Elsevier
… in the treatment of COPD and asthma. The … asthma treatment, oral roflumilast has been
proposed as a beneficial add-on therapy for use in patients with moderate-to-severe asthma