… The pituitary gland is a neuroendocrine gland that releases hormones into the bloodstream
to regulate growth, … In conclusion, we show that a novel function of Prop1 is to activate the RA …

… gene in an infant with CPHD and an enlarged pituitary gland. … , pituitary function monitoring
in patients with PROP1 … Many patients with PROP1 defects have growth failure in late infancy …

… of biallelic PROP1 variants of uncertain significance (or … Growth deficiency with
moderate-to-severe growth deceleration … of clomiphene citrate, which requires an intact pituitary …

… suggests that PROP1 has some role in corticotroph differentiation or viability. Since adrenal
… An enlarged pituitary gland may be mistaken for a tumor, leading to unnecessary surgery ( …

… Next, to analyze the function of PROP1, we examined its … the pituitary gland originate from
Prop1-expressing progenitors. … Prop1-expressing mice, non-functioning pituitary tumors or …

… The pituitary gland is a central regulator of growth, … to the role of the cell-type specific factors
(PROP1, POU1F1), other … In Prop1 deficient mice (Prop1/-) progenitor cells of the periluminal …

… , factors other than the PROP1 mutations, which result in an … the pituitary gland, have a
stronger impact on fetal growth and … between pituitary size and pituitary function in CPHD-PROP1 …

… , concern has been raised regarding its potential role in cancer initiation or promotion in rhGH
treated … The role of rhGH replacement in cancer occurrence in this subject is questionable. …

… of growth hormone (GH) and shortage of at least one or more other hormones of the pituitary
gland … that encode proteins for hypothalamic and pituitary gland function, or differentiation in …

… pituitary gland. It controls the proliferation and differentiation of endocrine lineages in the
formative pituitary gland, … this study confirm the role of PROP1 polymorphisms on growth traits in …