Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases
D Heras-Sandoval, JM Pérez-Rojas… - Cellular signalling, 2020 - Elsevier
… adenosine triphosphate (ATP)/adenosine monophosphate (AMP) ratio drops in the cell,
AMP-activated protein kinase … of p70 ribosomal S6 kinase (p70S6K) on Thr 389 by mTORC1 […
AMP-activated protein kinase … of p70 ribosomal S6 kinase (p70S6K) on Thr 389 by mTORC1 […
Aβ monomer induces phosphorylation of Tau at Ser‐214 through β2AR‐PKA‐JNK signaling pathway
H Wu, S Wei, Y Huang, L Chen, Y Wang… - The FASEB …, 2020 - Wiley Online Library
… kinase (JNK) at Thr-183/Tyr-185, p70 ribosomal protein S6 … Mitogen-activated protein kinase
kinase (MEK) mediated the … cyclic adenosine monophosphate response element binding …
kinase (MEK) mediated the … cyclic adenosine monophosphate response element binding …
Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)
KA Vessey, AI Jobling, MX Tran, AY Wang… - Autophagy, 2022 - Taylor & Francis
… ; AMPK: 5’ adenosine monophosphate-activated protein kinase APOE: … protein kinase
14; RPE: retinal pigment epithelium; RPS6KB/p70 S6 kinase: ribosomal protein S6 kinase…
14; RPE: retinal pigment epithelium; RPS6KB/p70 S6 kinase: ribosomal protein S6 kinase…
Role of autophagy on heavy metal-induced renal damage and the protective effects of curcumin in autophagy and kidney preservation
SH Avila-Rojas, A Lira-León, OE Aparicio-Trejo… - Medicina, 2019 - mdpi.com
… of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent
kinase (… B (AKT)/p70 ribosomal protein S6 kinase (p70S6K) pathway and linked to …
kinase (… B (AKT)/p70 ribosomal protein S6 kinase (p70S6K) pathway and linked to …
[HTML][HTML] Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells
JH Lee, KS Chung, HH Lee, D Ko, M Kang… - Biomedicine & …, 2021 - Elsevier
… target of rapamycin (mTOR), ribosomal protein S6 kinase (p70S6K), and signal transducer
… functions as a serine/threonine protein kinase that interacts with adenosine triphosphate and …
… functions as a serine/threonine protein kinase that interacts with adenosine triphosphate and …
The mTOR Complexes: Coordinating Metabolism and Translation
… [11], SIN1 (stress-activated protein kinase (SAPK)-interacting … to TSC1/2 signaling, via p90
ribosomal S6 kinase (RSK) that … activator CREM by the p70 S6 kinase: An alternative route to …
ribosomal S6 kinase (RSK) that … activator CREM by the p70 S6 kinase: An alternative route to …
Involvement of RSK phosphorylation in PTTH‐stimulated ecdysone secretion in prothoracic glands of the silkworm, Bombyx mori
SH Gu, CH Chen - Insect molecular biology, 2021 - Wiley Online Library
… Our results showed that PTTH stimulated p90 ribosomal S6 kinase (RSK) … protein kinases
included protein kinase A (PKA), protein kinase C (PKC), tyrosine kinase, p70 S6 kinase…
included protein kinase A (PKA), protein kinase C (PKC), tyrosine kinase, p70 S6 kinase…
Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of …
M Arioka, K Miura, R Han, K Igawa… - Life Sciences, 2024 - Elsevier
… (ACC) and the dephosphorylation of p70 S6 kinase with approximately the same potency.
DIF-1 and LW6 induced mitochondrial fission. Furthermore, … ribosomal protein S6 kinase …
DIF-1 and LW6 induced mitochondrial fission. Furthermore, … ribosomal protein S6 kinase …
Glibenclamide targets sulfonylurea receptor 1 to inhibit p70S6K activity and upregulate KLF4 expression to suppress non-small cell lung carcinoma
K Xu, G Sun, M Li, H Chen, Z Zhang, X Qian, P Li… - Molecular cancer …, 2019 - AACR
… The 70-kDa ribosomal S6 kinase (p70S6K) is a serine/threonine kinase (12). It is one of the
… target of rapamycin complex 1 (mTORC1) signaling pathway and plays important roles in cell …
… target of rapamycin complex 1 (mTORC1) signaling pathway and plays important roles in cell …
Canagliflozin inhibits glioblastoma growth and proliferation by activating AMPK
K Shoda, S Tsuji, S Nakamura, Y Egashira… - Cellular and Molecular …, 2023 - Springer
… of AMP-activated protein kinase (AMPK), p70 S6 kinase, and S6 ribosomal protein by …
Tumor cells including GBM rely preferentially on anaerobic glycolysis for adenosine triphosphate (…
Tumor cells including GBM rely preferentially on anaerobic glycolysis for adenosine triphosphate (…