Circulating osteogenic progenitor cells in mild, moderate, and severe aortic valve stenosis

M Al-Hijji, N Narula, JL Go, S Khosla… - Mayo Clinic …, 2019 - Elsevier
progenitor cells with osteoblastic phenotype (EPC-OCNs) and their role in individuals with
varying degrees of aortic stenosis (… Aortic valve calcification (AVC) is now felt to be an active, …

The shifting nature of endothelial progenitor cells in aortic stenosis

KI Boström - Mayo Clinic Proceedings, 2019 - mayoclinicproceedings.org
Calcific aortic valve disease: a consensus summary from the Alliance … osteogenesis. For
example, diabetes is known to affect both the bone marrow and circulating stem cell progenitors, …

Osteogenic circulating endothelial progenitor cells are associated with vascular aging of the large arteries in rheumatoid arthritis

YH Chan, MC Ngai, Y Chen, MZ Wu, YJ Yu… - … Interventions in Aging, 2022 - Taylor & Francis
… investigate the role of osteocalcin (OCN)-expressing circulating endothelial progenitor cells
(… with severe calcific aortic stenosis. Several other clinical studies respectively showed that …

Circulating Progenitor Cells Are Associated With Bioprosthetic Aortic Valve Deterioration: A Preliminary Study

Y Kanaji, I Ozcan, T Toya, R Gulati… - … of the American Heart …, 2023 - Am Heart Assoc
… bioprosthetic aortic valve replacement. Circulating progenitor cells might play a vital role in
… were associated with native calcific aortic valve stenosis. Although BVs lack valve interstitial …

Oxidized HDL, as a novel biomarker for calcific aortic valve disease, promotes the calcification of aortic valve interstitial cells

JT Sun, YY Chen, JY Mao, YP Wang, YF Chen… - Journal of …, 2019 - Springer
… , causes endothelial cell (EC) and endothelial progenitor cell (… with severe aortic stenosis
and were eligible for aortic valve … We also explored whether ox-HDL plays a role in osteogenic

[HTML][HTML] Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties

M Bogdanova, A Zabirnyk, A Malashicheva… - Scientific Reports, 2019 - nature.com
… The presence of circulating osteogenic precursor cells in patients with … and characterization
of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. …

Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients

YH Chan, MC Ngai, Y Chen, MZ Wu… - Annals of …, 2019 - Wiley Online Library
… the hypothesis that osteogenic circulating EPCs may have a pathogenic mechanistic role in
… Interventional studies that attempt to modulate osteogenic EPCs relevant to CV calcification

Human aortic valve interstitial cells display proangiogenic properties during calcific aortic valve disease

N Gendron, M Rosa, A Blandinieres… - … and Vascular Biology, 2021 - Am Heart Assoc
… mesenchymal stem cells (MSCs) 6 and circulating fibrocytes 7 … in VIC p osteogenic and
perivascular differentiation. … Other progenitor cells isolated from the heart are involved in cardiac …

[HTML][HTML] Molecular Features of Calcific Aortic Stenosis in Females and Males

E Le Nezet, C Marqueze-Pouey, I Guisle, MA Clavel - CJC Open, 2024 - Elsevier
… Their osteogenic transition seems inhibited by estrogen and … Estrogens may play a protective
role in the calcification of the aorticCirculating levels of testosterone have been positively …

Genetic and developmental contributors to aortic stenosis

P Dutta, JF James, H Kazik, J Lincoln - Circulation research, 2021 - Am Heart Assoc
… the endocardial and myocardial progenitor cells using an Nkx2.… of BAV and CAVD (calcific
aortic valve disease) in humans … risk factors in promoting osteogenic changes in VICs …