… retinopathy complications. In the current review, we investigated … roles of PARP-1 in diabetic
retinopathy and its potential applications in diabetic diagnosis and prognosis for purpose of …

… of diabetic complications including peripheral neuropathy. Citation2 Poly ADP-ribose polymerase
(… an important role in the initiation of apoptosis. Citation3,Citation4 PARP can catalyze …

… Poly ADP-ribose polymerase 1 (PARP1), a sensor of DNA damage, has been reported to
play a key role in DNA damage and repair (Krishnakumar & Kraus, 2010; Langelier et al., 2012)…

… AND FUNCTIONS OF PARP-1 Structure of PARP-1 PARPs are a family of enzymes that
catalyze the transfer of poly-ADP-ribose (PARs) to target proteins through a process called poly-…

… poly (ADP-ribose) polymerase enzyme induces a series of events resulting in polymers of
poly ADP-ribose (… Activation of PARP-1 in the nucleus leads to mitochondrial dysfunction. This …

… PARP1 is catalytically activated in response to DNA damage to consume NAD and form
polymers of ADP-ribose (PAR) that … 26 and retinopathy 27 is well documented. In contrast, the …

… In this review, we comprehensively synthesize and explore the multifaceted role of PARP1
in neurodegenerative diseases, with a particular emphasis on its over-activation in the …

… This review focuses on the pathophysiology of diabetic neuropathy and the possible …
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and …

… PARP activation was postulated to contribute to fibrosis allied with diabetes-induced nephropathy
through poly … to reduce glomerular fibrosis associated with diabetic nephropathy [24]. …

… tissues; for example, PARP1 activation by DNA damage caused by oxidative stress is believed
to play a role in diabetic neuropathy (239, 240). The roles of PARP in inflammation have …