The critical roles and mechanisms of immune cell death in sepsis

Z Cheng, ST Abrams, J Toh, SS Wang, Z Wang… - Frontiers in …, 2020 - frontiersin.org
… consequences of infection-induced extensive immune cell death during the development of
sepsis. … susceptible to programmed cell death, many other types of immune cells including …

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
… regulatory T (Treg) cell expression, expression of programmed cell death (PD)-1 on CD4 + T
… innate and adaptive immune response is involved in the pathogenesis of sepsis. The peak …

[HTML][HTML] Immunopathophysiology of human sepsis

WJ Wiersinga, T van der Poll - EBioMedicine, 2022 - thelancet.com
… mechanisms involved in sepsis, which are … immunopathogenesis of sepsis and highlight
some recent pathophysiological findings that have expanded our understanding of sepsis

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
… (injury or infection, etc.) states, cells adopt different cell death pathways which generate …
cells die each day to maintain a healthy turnover of cells (48). Programmed Cell Death (PCD…

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. … during sepsis and recent initiatives to stratify patients with sepsis into …

Role of the adaptive immune response in sepsis

J Brady, S Horie, JG Laffey - Intensive care medicine experimental, 2020 - Springer
… also shown to possess elevated levels of programmed cell death ligand 1 (PD-L1) [… cells
from individuals with sepsis is associated with a reduction of the proliferative capacity of T cells

Programmed necrosis and disease: we interrupt your regular programming to bring you necroinflammation

EH Kim, SW Wong, J Martinez - Cell Death & Differentiation, 2019 - nature.com
programmed cell deathsepsis models via cell death-independent mechanisms, and
RIPK3 deficiency also limits viral pathogenesis of West Nile Virus (WNV) independently of cell

Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
… molecules [such as programmed cell death 1 (PD-1), T-cell immunoglobulin and mucin …
A comprehensive understanding of the pathogenesis may provide new ideas and strategies …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
… regarding the cellular pathogenesis and the target of clinical diagnosis of sepsis, with the …
includes a decrease in HLA-DR, lymphocyte replication, programmed cell death/apoptosis

Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/PD-L1 pathway

Y Nakamori, EJ Park, M Shimaoka - Frontiers in immunology, 2021 - frontiersin.org
… restore immune dysregulation in sepsis has been validated in … the programmed cell death
protein 1/programmed death ligand … The roles of exosomes in the pathogenesis of sepsis have …