P2Y receptors in neuropathic pain

X Zhang, G Li - Pharmacology Biochemistry and Behavior, 2019 - Elsevier
… , P2Y6, P2Y12 and P2Y13 receptors with neuropathic pain. … P2Y receptors; (2) P2Y11 is an
ATP-preferring P2Y receptor; (… Spared nerve injury (SNI) Mice MRS2578 (P2Y6 antagonist) …

[HTML][HTML] P2Y12 receptor involved in the development of chronic nociceptive pain as a sensory information mediator

W Zhang, M Li, C Wang, X Feng, D Hu, L Wu… - Biomedicine & …, 2023 - Elsevier
… the role of the P2Y12 receptor in different chronic pains and its use … This reflects the
involvement of P2Y12 receptor in pain and … P2Y12 receptor signaling in spinal microglia of mice

Treatment of chronic neuropathic pain: purine receptor modulation

KA Jacobson, LA Giancotti, F Lauro, F Mufti… - Pain, 2020 - journals.lww.com
… For example, involvement of P2XRs has been explored in … P2X4R knockout (KO) mice
displayed normal acute pain … in the spinal dorsal horn, to increase neuropathic pain. …

Natural compounds acting at P2 receptors alleviate peripheral neuropathy

L Zou, Y Gong, S Liu, S Liang - Brain research bulletin, 2019 - Elsevier
… data on P2 receptor-mediated neuropathic pain and myocardial … P2Y1, P2Y2, P2Y4, P2Y6
and P2Y11 couple to Gq proteins … -induced neuropathic pain rats compared to control rats and …

[HTML][HTML] Role of microglia and P2X4 receptors in chronic pain

K Kohno, M Tsuda - Pain Reports, 2021 - journals.lww.com
… of chronic pain 120 This study also found that mice lacking … , 51 assuming a possible
involvement of CSF1 in producing … In summary, spinal microglia undergo activation in a variety …

Central role of purinergic receptors with inflammation in neuropathic pain-related macrophage-SGC-neuron triad

R Yang, J Du, L Li, X Xu, S Liang - Neuropharmacology, 2023 - Elsevier
P2Y6 receptors are upregulated during the differentiation of … and P2Y11 receptors, the
duration is determined by P2X4 … , pointing to a potential involvement of these receptors in neuron-…

P2Y1 purinergic receptor inhibition attenuated remifentanil-induced postoperative hyperalgesia via decreasing NMDA receptor phosphorylation in dorsal root …

L Su, X Bai, T Niu, X Zhuang, B Dong, G Wang… - Brain Research …, 2021 - Elsevier
role in neuropathic pain. The contribution of the P2Y1 purinergic … In order to verify the
possible involvement of NMDAR … infusion in incision pain rats. These results suggest the …

[HTML][HTML] P2X receptors and acupuncture analgesia

Y Tang, H Yin, J Liu, P Rubini, P Illes - Brain research bulletin, 2019 - Elsevier
involvement of purinoceptors (P2 and P1/A1 receptors) in the beneficial effects of AA. In view
of certain pain states (eg neuropathic pain) … In rat neuropathic pain induced by constricting …

Microglial P2Y14 receptor contributes to central sensitization following repeated inflammatory dural stimulation

P Zhu, X Dong, H Xu, Q Wan, Q Guo, J Wang… - Brain research …, 2021 - Elsevier
… the participation of spinal P2Y6 and P2Y11 receptors in the maintenance of neuropathic pain
[25]. … that the P2Y14 receptor is increased in microglia in migraine rat model and the P2Y14 …

Potential therapeutic applications of P2 receptor antagonists: from bench to clinical trials

NC da Silva Ferreira, LA Alves… - Current Drug …, 2019 - ingentaconnect.com
… P2Y2 plays a role in trigeminal neuropathic pain, and the use of antisense oligonucleotides,
Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement