Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

KR Chng, C Li, D Bertrand, AHQ Ng, JS Kwah… - Nature medicine, 2020 - nature.com
… isolates indicated that such microbes can persist in hospitals … the importance of characterizing
antibiotic resistance … for multidrug resistance in derivative clusters (binomial test P value < …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - Am Soc Microbiol
antibiotic resistance have an applied aspect in improving individual health, One Health, and
Global Health, as well as an academic value … These functions have the potential to reduce …

Chlorine injury enhances antibiotic resistance in Pseudomonas aeruginosa through over expression of drug efflux pumps

A Hou, D Yang, J Miao, D Shi, J Yin, Z Yang, Z Shen… - Water research, 2019 - Elsevier
… ), a normalized value generated from … regulated (1.5 fold) after exposure for 20 min; this
suggests that the MexEF-OprN efflux pump plays a key role in generation of antibiotic resistance

[HTML][HTML] Copper nanoparticles and copper ions promote horizontal transfer of plasmid-mediated multi-antibiotic resistance genes across bacterial genera

S Zhang, Y Wang, H Song, J Lu, Z Yuan, J Guo - Environment international, 2019 - Elsevier
… The findings provide insights into the roles of both CuO NPs … The maximum value was
observed at the CuO NPs dosage of … test, and genome-wide RNA and protein sequencing were …

Recent progress in natural-product-inspired programs aimed to address antibiotic resistance and tolerance

Y Abouelhassan, AT Garrison, H Yang… - Journal of medicinal …, 2019 - ACS Publications
… the value of semisynthesis for antibacterial discovery and … that bacteria require to thrive and
is known to play critical roles in … On the basis of RNA-seq findings, we believe HP-14 induces …

Antimicrobial resistance, mechanisms and its clinical significance

MA Abushaheen, AJ Fatani, M Alosaimi, W Mansy… - Disease-a-Month, 2020 - Elsevier
RNA polymerase, which is the main target of this antibiotic. … , antibiotics are generally sold
at a maximum price of $3000 … play a key role in preventing antimicrobial resistance. Therefore, …

Omics of antimicrobials and antimicrobial resistance

VM Chernov, OA Chernova… - Expert opinion on …, 2019 - Taylor & Francis
role played by membrane vesicles in antimicrobial resistance. Extracellular vesicles, transporting
a wide range of molecules and macromolecules (proteins, lipids, DNA, and RNA)… RNAs

Effect of nutritional energy regulation on the fate of antibiotic resistance genes during composting of sewage sludge

H Wei, J Ma, Y Su, B Xie - Bioresource Technology, 2020 - Elsevier
… community, metabolic function as well as ARGs via regulation of carbon … value is a key
indicator of salinity during the sludge composting with fermented straw, suggesting the possible

Characterization of antibiotic resistance genes in the species of the rumen microbiota

YNV Sabino, MF Santana, LB Oyama… - Nature …, 2019 - nature.com
… resistange gene profiles of the main species of ruminal bacteria and reveal the potential role
… Minimum inhibitory concentration (MIC values) were determined using the Epsilometer test (…

Antibiotic resistance and persistence—Implications for human health and treatment perspectives

M Huemer, S Mairpady Shambat, SD Brugger… - EMBO …, 2020 - embopress.org
… on one plasmid and are thereby transmissible between bacteria, highlighting the importance
of MDR efflux pumps as a major … High MDK 99 values indicate high antibiotic persistence. …