Ruthenium complexes: An alternative to platinum drugs in colorectal cancer treatment
Colorectal cancer (CRC) is one of the intimidating causes of death around the world. CRC
originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair
genes. Though platinum (Pt)-based anticancer drugs have been widely used in the
treatment of cancer, their toxicity and CRC cells' resistance to Pt drugs has piqued interest in
the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed
promising anticancer activity due to their unique chemical properties. Ru-complexes are …
originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair
genes. Though platinum (Pt)-based anticancer drugs have been widely used in the
treatment of cancer, their toxicity and CRC cells' resistance to Pt drugs has piqued interest in
the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed
promising anticancer activity due to their unique chemical properties. Ru-complexes are …
[PDF][PDF] Ruthenium complexes: an alternative to platinum drugs in colorectal cancer treatment. Pharmaceutics 2021; 13: 1295
Colorectal cancer (CRC) is one of the intimidating causes of death around the world. CRC
originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair
genes. Though platinum (Pt)-based anticancer drugs have been widely used in the
treatment of cancer, their toxicity and CRC cells' resistance to Pt drugs has piqued interest in
the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed
promising anticancer activity due to their unique chemical properties. Ru-complexes are …
originated from mutations of tumor suppressor genes, proto-oncogenes and DNA repair
genes. Though platinum (Pt)-based anticancer drugs have been widely used in the
treatment of cancer, their toxicity and CRC cells' resistance to Pt drugs has piqued interest in
the search for alternative metal-based drugs. Ruthenium (Ru)-based compounds displayed
promising anticancer activity due to their unique chemical properties. Ru-complexes are …
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