Rotavirus vaccine safety and effectiveness in infants with high-risk medical conditions

JAP van Dongen, EDM Rouers, R Schuurman… - …, 2021 - publications.aap.org
against severe rotavirus acute gastroenteritis (AGE) in healthy infants in high-income countries.
Little is known whether infants with medical risk conditions (MRCs) are equally protected …

Effectiveness of Lanzhou lamb rotavirus vaccine in preventing gastroenteritis among children younger than 5 years of age

J Li, Y Zhang, Y Yang, Z Liang, Y Tian, B Liu, Z Gao… - Vaccine, 2019 - Elsevier
… In this study, the LLR vaccine was effective to protect people from severe rotavirus infection
(… studies about LLR vaccine, in which higher VE estimate was got in severe cases compared …

[HTML][HTML] Overview of the development, impacts, and challenges of live-attenuated oral rotavirus vaccines

OS Folorunso, OM Sebolai - Vaccines, 2020 - mdpi.com
… All licensed RoVs are live-attenuated vaccines capable of reassorting with … against
severe and very severe rotavirus infection in Botswana [204]. However, the severity of infection

[HTML][HTML] Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials

A Clark, K van Zandvoort, S Flasche… - The Lancet Infectious …, 2019 - thelancet.com
Safety and efficacy of an attenuated vaccine against severe … The outcome measure was
efficacy against episodes of severe rotavirus gastroenteritis, which is the primary endpoint …

[HTML][HTML] Effectiveness of oral rotavirus vaccination in England against rotavirus-confirmed and all-cause acute gastroenteritis

JL Walker, NJ Andrews, CJ Atchison, S Collins… - Vaccine: X, 2019 - Elsevier
… testing during this period may, therefore, lead to a misdiagnosis of rotavirus gastroenteritis.
Whilst the attenuated vaccine strain may cause mild symptoms including diarrhoea in some …

Safety and immunogenicity of a novel oral hexavalent rotavirus vaccine: a phase I clinical trial

ZW Wu, QL Li, HS Zhou, K Duan, Z Gao… - Human vaccines & …, 2021 - Taylor & Francis
… strategy to prevent rotavirus infection. This study evaluated the safety of a novel hexavalent
rotavirus vaccine and analyzed … As a live vaccine, transmission of vaccine virus strains from …

[HTML][HTML] Understanding rotavirus vaccine efficacy and effectiveness in countries with high child mortality

T Varghese, G Kang, AD Steele - Vaccines, 2022 - mdpi.com
… modest efficacy, the number of severe rotavirus gastroenteritis episodes and diarrheal deaths
prevented with these vaccines … For instance, the number of severe rotavirus gastroenteritis

Association of rotavirus vaccines with reduction in rotavirus gastroenteritis in children younger than 5 years: a systematic review and meta-analysis of randomized …

ZW Sun, Y Fu, HL Lu, RX Yang, H Goyal… - JAMA …, 2021 - jamanetwork.com
vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants:
a … Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis.  …

[HTML][HTML] … the immunogenicity and safety of the live, attenuated, oral rotavirus vaccine, ROTAVAC® in comparison with a licensed rotavirus vaccine in healthy infants

R Ella, S Babji, M Ciarlet, WC Blackwelder… - Vaccine, 2019 - Elsevier
… naturally from the human 116E rotavirus (RV) neonatal strain, … , safety and efficacy vaccine
trial. As a pre-requisite for WHO prequalification, we compared the immunogenicity and safety

Fifteen years of experience with the oral live-attenuated human rotavirus vaccine: reflections on lessons learned

P Pereira, V Vetter, B Standaert… - … Review of Vaccines, 2020 - Taylor & Francis
… acceptable safety profile and efficacy against RV-gastroenteritis, providing broad protection
… at-risk categories for which live-attenuated vaccines are not recommended (eg, children with …