… a novel Lyme borreliosis vaccine candidate (VLA15) targeting the six most common outer
surface protein A (OspA) … a multivalent Lyme borreliosis vaccine candidate that was safe and …

… afzelii OspA ST2, the most important Borrelia species … that the novel multivalent OspA-based
vaccine approach has the … of the linker sequence to immunogenicity and protection was …

… The V H Hs displayed unique reactivity profiles with the seven OspA … OspA serotypes that
should be considered when designing and evaluating multivalent Lyme disease vaccines. …

… Nanoparticle delivery of the OspA antigen is a novel vaccine approach to Lyme disease. We
… , OspA, in its natural conformation in an ordered multivalent array to improve immunogenicity…

… the current modifications of recombinant OspA to develop a multivalent subunit vaccine for
Lyme … The safety and immunogenicity of the rOspA vaccine was again tested in 30 healthy …

… serum antibody titers against a single epitope near the C-terminus of OspA, as … OspA following
vaccination remains undefined even as next-generation multivalent OspA-based vaccines …

… Lyme disease vaccine based on lipidated recombinant OspA, … Multivalent approaches in
Lyme disease vaccines have … Immunogenicity of Lyme disease vaccinogens can potentially be …

… In contrast, VLA15 is a multivalent vaccine that contains OspA C-terminals from multiple …
and colleagues evaluated the safety, tolerability, and immunogenicity of VLA15 by administering …

… to test a new multivalent OspA vaccine designed to prevent Lyme disease in both the
United … developed a multivalent OspA Lyme borreliosis vaccine (mv rOspA LB vaccine) that …

… Immunogenicity was determined as the number of IgG antibodies against each of the six
most prevalent OspA … VLA 15 vaccine (Valneva, France) is a multivalent OspA vaccine contain…