… synthesized an OspA-encoding mRNA-LNP vaccine and compared its immunogenicity and
… development of an OspA mRNA-LNP construct with superior immunogenicity and efficacy to …

… of strong immunogenicity and convenient production, safety issues of … into Lyme disease
vaccine continues to focus on multivalent vaccines that contain antigen epitopes of OspA. Such …

… both OspA and OspC, antibody levels against these proteins … to veterinary vaccines against
Lyme disease and will help … being immunogenic, efficacy of veterinary LD vaccines in the …

… protein conferred protection against Lyme Borrelia infection, making it a promising vaccine
candidate. … Therefore, any OspA vaccine would only induce memory immunity via continuous …

… In contrast to relapsing fever, spirochetemias are not common in mammals infected with
Lyme disease. (B) A transmission electron micrograph of the oral spirochete Treponema …

… OspA to OspC [6]. The idea emerged that by immunizing mice with OspA, specific antibodies
against OspA … In this context, a thorough study of FlaB immunogenicity in Lyme borreliosis …

… Immunogenicity and vaccine efficacy were … vaccines to control Lyme disease. We developed
a parainfluenza virus 5 (PIV5) viral-vectored vaccine for intranasal delivery of OspA that …

… Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in
healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial. Lancet Infect Dis …

… GmbH designed multivalent OspA-based vaccine derived from multiple OspA serotypes, …
Aim I: Evaluate the immunogenicity and efficacy of the PepB formulated in a protein scaffold …

… The vaccine proved itself to be safe with minimal adverse effects, well-tolerated, and immunogenic
in healthy adults. The 30 … This multivalent OspA vaccine targeting different pathogenic …