… prevalent illnesses are represented by Lyme disease (LD) (… In Europe, human trials with a
modified OspA vaccine against … These vaccines showed a high level of immunogenicity and …

… Lyme disease.” A vaccine targeting the outer surface protein A (OspA) in Lyme … A new
multivalent vaccine targeting six serotypes of the same OspA has recently undergone …

… In this study, the primary focus was to evaluate the infection rate of Lyme disease Borrelia in
… -time PCR targeting the ospA gene for detection of Borrelia burgdorferi sensu lato DNA in …

… immunogenicity, selecting adjuvants, establishing vaccine formulation, demonstrating
protective efficacy against lethal disease in … by oral immunization, as observed with the OspA …

… vaccine for tick-borne encephalitis virus, but a vaccine targeting Borrelia burgdorferi, the
causative agent of Lyme disease, … few vaccines licensed for arthropod vector-borne disease and …

… , VLPs can display multivalent antigenic epitopes on their … Lyme disease is the most
common vector-borne infectious … OspA mRNA-LNP may prove to be a viable method for Lyme …

… as an attractive platform for vaccine generation [17]. In addition, ferritin is capable of a
multivalent display of antigen molecules, and a multivalent presentation of antigens generally …

… We particularly focus on the preclinical and clinical progress of highly immunogenic … (OspA)
antigen from B. burgdorferi to form a preventive vaccine (LYMErix™) against Lyme disease. …

… vaccine composed of a single protein is a recombinant OspA vaccine for the purpose of
preventing Lyme disease … in live multivalent vaccines than in killed multivalent vaccines. Thus, …

… Fusing multiple immunogenic antigens represents a promising … Multivalent vaccines are
required in Brazil, where multiple … rBCG instability expressing OspA has been considered a …