… Inspired by the natural product evodiamine, a novel … to their synthetic accessibility and
chemical diversity (Figure 2). In … a number of derivatives offered highly potent activity against the …

… Inspired by this, we carried out a more comprehensive … Diverse substituted evodiamine
derivatives were synthesized as … was screened to be the most potent candidate of the series. It …

… , is considered a desirable lead scaffold as its multifunctional … modifications of Evo to discover
novel anticancer drugs. … 2 derivative 63 exhibited the most potent cytotoxicity against MDA-…

… , a library of compounds containing 11 EVOinspired diverse scaffolds (21-31) and their …
Scaffold diversity inspired by the natural product evodiamine: Discovery of highly potent and …

… novo construction of natural product-like molecular scaffolds. … The most potent analog of
the library, BRD0476, restored … In this case, the main structure of evodiamine was modified …

… Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and exhibits
moderate antiproliferative activity. Herein, we report using a scaffold-… The most potent …

… In order to improve the antitumor potency of the natural product evodiamine, novel boron-containing
evodiamine derivatives were designed by incorporating boronic acid and boronate …

… the discovery of compound 45, which displayed highly potent … optimization of evodiamine
in our lab led to the discovery of a … , 23 Moreover, diverse evodiamine-inspired scaffolds were …

… Encouraged by the relatively high selectivity of 7b/(S)-7b plus their novel EVO scaffold …
2) so as to discover leads with strong binding affinity and high isoform selectivity, following the …

… Inspired by antitumor natural product evodiamine, a series of novel bis-evodiamine derivatives
were designed … Inspired by antitumor natural product evodiamine, a series of novel bis-…