Proton pump inhibitors prevent gastric antral ulcers induced by NSAIDs via activation of capsaicin-sensitive afferent nerves in mice

H Satoh, Y Akiba, T Urushidani - Digestive Diseases and Sciences, 2020 - Springer
… Indomethacin produced lesions selectively in the … and capsaicin on ulcer formation
were inhibited by ablation of CSANs, pretreatment with a capsaicin receptor antagonist (capsazepine/…

[HTML][HTML] Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions

YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
… of vagal and spinal afferent nerve fibers by capsaicin, acid, … , support by functional evidence
greatly increase their validity. … , whereas cell exposure to capsaicin induced Ca 2+ influx and …

Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1

A Hatta, M Kurose, C Sullivan… - Journal of …, 2019 - journals.physiology.org
Capsaicin-induced changes were prevented by the application of the TRPV1 antagonist
capsazepine. … might reflect an increase in TRPV1 receptors in TRPM8-positive corneal cells, as …

Capsaicin and TRPV1 channels in the cardiovascular system: the role of inflammation

S Munjuluri, DA Wilkerson, G Sooch, X Chen, FA White… - Cells, 2021 - mdpi.com
… known to exhibit antinociceptive properties by desensitizing … [56] provided evidence that
capsaicin-induced stimulation of … capsazepine or SB-366791 or inhibition of the CB2 receptor

[HTML][HTML] The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review

L Li, C Chen, C Chiang, T Xiao, Y Chen… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
… be inhibited by the antagonists capsazepine and I-RTX 97 . Capsaicin induced apoptosis in
… However, this report does not include direct evidence to show if the synergism was exerted …

Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene) cyclohexen-1-ol, and its possible mechanisms of action …

HM Ong, AFA Azmi, SW Leong, F Abas, EK Perimal… - Scientific Reports, 2021 - nature.com
… any sedative action and no evidence of acute toxic effect was … Our current results demonstrated
the capsaicin-induced pain … of capsazepine, a selective capsaicin receptor antagonist. It …

[HTML][HTML] TRP channels in cancer pain

AS de Almeida, L de Barros Bernardes… - European journal of …, 2021 - Elsevier
… The antinociceptive effects of cannabinoid receptor subtypes … peppers), capsazepine (a
TRPV1 non-selective antagonist), … Furthermore, LPA can increase capsaicin-induced currents …

Effective suppression of Ih and INa caused by capsazepine, known to be a blocker of TRPV1 receptor

SL Wong, CL Shih, HY Cho, SN Wu - Brain Research, 2024 - Elsevier
… A synthetic inhibitor of capsaicin-induced TRPV1 channel … Results from the current
experimental work provide evidence … not connected with its antagonistic effect on vanilloid …

Effect of Arbutus andrachne L. methanolic leaf extract on TRPV1 function: Experimental and molecular docking studies

S Jaffal, S Oran, M Alsalem… - Journal of Applied …, 2022 - japsonline.com
… that the extract decreased capsaicin-induced cobalt (Co+2) … pocket of TRPV1 receptor
similar to capsazepine, indicating … produces antinociceptive activity involving TRPV1 receptors, …

[PDF][PDF] 2ʹ, 3, 3, 5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1, 3ʹ-bipyrazole exerts antinociceptive effect using various nociception models

Y Bseiso, A Alqudah, E Qnais, M Wedyan… - …, 2023 - pharmacia.pensoft.net
… the supraspinal and spinal biological properties of novel drugs, … capsaicin-induced and
glutamate-induced paw-licking tests. … produced by capsazepine, a well-known TRPV antagonist. …