Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain

Y Matsushita, M Manabe, I Kitagawa… - Journal of Veterinary …, 2021 - jstage.jst.go.jp
… α2 receptors suppresses capsaicin-induced neurotransmitter … as a more specific TRPV1
antagonist than capsazepine in this … capsazepine antinociceptive effect in formalin and capsaicin

Capsaicin for weight control:“Exercise in a pill”(or just another fad)?

A Szallasi - Pharmaceuticals, 2022 - mdpi.com
… the available evidence for and against capsaicin as a weight … was prevented by capsazepine,
a TRPV1 antagonist [91], … The central efferents enter the spinal cord where they make …

Modulation of TRPV1 channel function by natural products in the treatment of pain

MA Abbas - Chemico-biological interactions, 2020 - Elsevier
… with spinal cord injuries also experience chronic pain [3]. … by capsazepine when
subcutaneously-injected in rat paw. … an antinociceptive effect in the intraplantar capsaicin -induced

Hypersensitivity induced by intrathecal bradykinin administration is enhanced by N-oleoyldopamine (OLDA) and prevented by TRPV1 antagonist

E Uchytilova, D Spicarova, J Palecek - International Journal of Molecular …, 2021 - mdpi.com
… Our present study provides evidence that intrathecal … of spinal TRPV1 to peripherally injected
capsaicin-induced B … Our present work showed that spinal TRPV1 receptors are crucial for …

2ʹ, 3, 3, 5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1, 3ʹbipyrazole exerts antinociceptive effect using various nociception models.

Y Bseiso, A Alqudah, E Qnais… - Pharmacia (0428 …, 2023 - search.ebscohost.com
… the supraspinal and spinal biological properties of novel drugs, … capsaicin-induced and
glutamate-induced paw-licking tests. … produced by capsazepine, a well-known TRPV antagonist. …

[PDF][PDF] 2ʹ, 3, 3, 5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1, 3ʹ-bipyrazole exerts antinociceptive effect using various nociception models. Pharmacia 70 (3): 509–517

Y Bseiso, A Alqudah, E Qnais, M Wedyan… - 2023 - pharmacia.pensoft.net
… the supraspinal and spinal biological properties of novel drugs, … capsaicin-induced and
glutamate-induced paw-licking tests. … produced by capsazepine, a well-known TRPV antagonist. …

TRPV1 ion channel: Structural features, activity modulators, and therapeutic potential

IN Gladkikh, OV Sintsova, EV Leychenko… - Biochemistry (Moscow …, 2021 - Springer
… However, the capsaicin-induced currents measured at 47C … using capsaicin (selective
agonist) or capsazepine (classical … Capsazepine introduced into the spinal cord also attenuated …

Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio)

FCO Silva, JESA de Menezes, MKA Ferreira… - Biochemical and …, 2020 - Elsevier
… -1 decreased capsaicin-induced nociception behavior in rodents by acting on TRPs receptors
[36]… (corneal) was prevented by ruthenium red and capsazepine, both TRPV1 antagonists. …

Natural products and some semi-synthetic analogues as potential TRPV1 ligands for attenuating neuropathic pain

GG Naik, A Uniyal, D Chouhan… - Current …, 2022 - ingentaconnect.com
… approach to decipher capsaicin-induced sodium and calcium … inhibited by capsazepine, a
competitive Vanilloid receptor antagonist [84]… Antinociception in rats was produced by systemic …

Antiallodynic effect of PhAR‐DBH‐Me involves cannabinoid and TRPV1 receptors

GN Quiñonez‐Bastidas… - Pharmacology …, 2020 - Wiley Online Library
receptor and is prevented by capsazepine. In line with our results, two previous studies reported
that capsaicin-inducedevidence supports and highlights the antinociceptive multi-target …