[HTML][HTML] A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
CA Amaya-Rodriguez, K Carvajal-Zamorano… - Frontiers in …, 2024 - frontiersin.org
… Capsazepine is a synthetic compound structurally similar to capsaicin and is a classic
antagonist … Evidence of the existence of structurally defined modules in thermoTRP channels …
antagonist … Evidence of the existence of structurally defined modules in thermoTRP channels …
[HTML][HTML] The role of toxins in the pursuit for novel analgesics
… It has been proposed that the anti-nociception induced by … visceral pain and reduced
capsaicin-induced mechanical hyperalgesia in … Numerous lines of evidence have demonstrated …
capsaicin-induced mechanical hyperalgesia in … Numerous lines of evidence have demonstrated …
[HTML][HTML] Transient receptor potential channels: important players in ocular pain and dry eye disease
D Fakih, T Migeon, N Moreau, C Baudouin… - Pharmaceutics, 2022 - mdpi.com
… These findings contribute to evidence suggesting that drugs … that WIN suppressed
capsaicin-induced cation channel currents … the application of a TRPV1 antagonist (capsazepine). …
capsaicin-induced cation channel currents … the application of a TRPV1 antagonist (capsazepine). …
Implications of transient receptor potential cation channels in migraine pathophysiology
M Shibata, C Tang - Neuroscience bulletin, 2021 - Springer
… by the TRPV1 inhibitor capsazepine, TRPV1 is likely to be … There is anatomical evidence
for meningeal nociceptors that … differing effects on capsaicin-induced pain depending on the …
for meningeal nociceptors that … differing effects on capsaicin-induced pain depending on the …
Effects of sulfide and polysulfides transmitted by direct or signal transduction‐mediated activation of TRPA1 channels
… Recent papers have presented evidence that TRPA1 … but potentiation of the capsaicin-induced
response by NaHS was … by a TRPA1 channel antagonist but also by capsazepine. Similar …
response by NaHS was … by a TRPA1 channel antagonist but also by capsazepine. Similar …
Analgesic potential of terpenes derived from Cannabis sativa
E Liktor-Busa, A Keresztes, J LaVigne… - Pharmacological …, 2021 - ASPET
… Increasing preclinical and clinical evidence suggests that … anti-inflammatory and antinociceptive
effects. The aim of this … The aim of this review is to collate available scientific evidence …
effects. The aim of this … The aim of this review is to collate available scientific evidence …
17 Treating Visceral Pain Via Molecular Targets on Afferent Neurons: Current and Future
GI HYPERSENSITIVITY - taylorfrancis.com
… Capsaicin-induced gating of TRPV1 stimulates extrinsic afferents … site of the antinociceptive
action of NK1 receptor antagonists is … Capsazepine: a competitive antagonist of the sensory …
action of NK1 receptor antagonists is … Capsazepine: a competitive antagonist of the sensory …
[HTML][HTML] A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
CA Amaya-Rodriguez, K Carvajal-Zamorano… - Frontiers in …, 2024 - frontiersin.org
… Capsazepine is a synthetic compound structurally similar to capsaicin and is a classic
antagonist … Evidence of the existence of structurally defined modules in thermoTRP channels …
antagonist … Evidence of the existence of structurally defined modules in thermoTRP channels …
[HTML][HTML] IUPHAR review: Navigating the role of preclinical models in pain research
… of NMDA and cannabinoid receptor antagonists. We also … , "There is substantial evidence
that the skin is equipped with … changes occurring at peripheral, spinal, and cerebral levels, …
that the skin is equipped with … changes occurring at peripheral, spinal, and cerebral levels, …
[HTML][HTML] Understanding diverse TRPV1 signaling–an update
MC Andresen - F1000Research, 2019 - ncbi.nlm.nih.gov
… antagonists are effective in blocking agonist (capsaicin or RTX) … NTS 69 , in contrast to
capsazepine block of heat responses in … Central relays for behavioral antinociception and arterial …
capsazepine block of heat responses in … Central relays for behavioral antinociception and arterial …