… N-terminal region of huntingtin (htt). Even though mutant huntingtin (mHTT) is ubiquitously
expressed throughout the body, it causes selective neuronal degeneration, particularly in the …

… selectively reduce the mutant huntingtin level in cellular models of HD. The purpose of this
study was to test the efficacy, selectivity, … to the brains of YAC128 mice via intrastriatal injection …

… (≥60%) nuclear localization. A deeper investigation into the … This change might be due to
selective degeneration of … we used the B97-ΔN17 and YAC128 mouse models due to their …

… the effects of mutant huntingtin on mitochondrial parameters … of HD is the selective
degeneration of the basal ganglia, with … increased in old YAC128 compared to young YAC128 …

… Lowering mHTT in the brain of YAC128 mice is not sufficient to rescue aberrant palmitoylation.
However, we demonstrate that mHTT palmitoylation can be normalized in COS-7 cells, in …

… Although striatal and cortical neurons eventually degenerate… selective DAPK1 inhibitor
(TC-DAPK6) decreased exGluN2B pS1303 levels in cortical tissue from 4-week-old YAC128 mice…

… Mice showed increased neuronal activity on the rotarod, which diminished by late stages of
learning. 2–3-month-old YAC128 mice … Striatal degeneration has been shown in R6/2 mice …

… mutant HTT mRNA in pathology or pathogenesis. Here we report that in two HD mouse models,
YAC128 and BACHD-97QΔN17, mutant … mechanism of selective striatal degeneration in …

… We also show that latent toxoplasmosis also promotes cortical degeneration in wild-type
mice. These findings are relevant to understanding a potential link between latent …

… under clinical development for Huntington disease (HD), has … callosum (CC) in the YAC128
HD mice. However, the nature … motor function deficits in YAC128 HD mice, and confirmed its …