… I would like to thank Professor Ivan Green for the guidance … corresponding quinones (for
example the 3,4−quinones) can form … known as selective estrogen receptor modulators (SERMs) …

… prevention with selective estrogen receptor modulators and … These, in turn, are converted
to quinone derivatives, which … prior mammograms and measure the same lesion to calculate …

… metabolites from estrogen (mainly estradiol-3, 4-quinone) in … Selective estrogen receptor
modulators (SERMs) inhibit … The same procedure was used for the synthesis of 3b and 3c. …

… The usage of selective estrogen receptor modulators (SERMs) … of different types, involving
orchiectomy, luteinizing hormone-… different expression levels of these two estrogen receptors. …

… The different mechanism of action of the said drugs makes … cells, which conjugates by
reacting with COOH groups, folic … because of the varied quinone and ketone carbonyls of DOX. …

… SN2 and SN1 reactions and quinone metabolites of naphthalene (… Lasofoxifene is also a
naphthalene derivative with a … ER-α in the similar way to that of estradiol but has at least 10-fold …

… Lasofoxifene (Fablyn)–a nonsteroidal SERM undergoes … different types of the cancer,
different stages of the disease and … Such enzymes include NAD(P)H:quinone oxidoreductase (…

… of WT and mutant ER with similar efficacy, downregulated ER- … selective estrogen receptor
modulators (SERMs), and … The SERM, lasofoxifene, which was originally developed for the …

… their metabolite profiles were similar to those observed in … and formed the reactive
intermediate, quinone-imine, which … eration selective estrogen receptor modulator, lasofoxifene, in …

… successful drugs like tamoxifen, raloxifene, and lasofoxifene, … , forming pro-oxidant species
(quinones/semiquinones) in the … the same group suggested that other thiol-reactive phenolic …