… the selective estrogen receptor modulators (SERMs… clinical use of SERMs such as tamoxifen,
the key characteristic underlying the therapeutic potential of SARMs is their tissue specificity…

… Direct targeting of ERα is achieved by selective estrogen receptor modulator (SERM) (eg, …
for ER binding and show mixed agonist/antagonist capabilities in a tissue-specific fashion. …

… specific type of breast cancer for more than 30 years. Selective estrogen receptor modulators
… with other growth signaling pathways impedes the clinical utility of SERMs and/or AIs. …

… (AIs), selective estrogen receptor modulators (SERMs), and selective estrogen receptor
degraders (SERDs… -sensitive MBC will be informative in helping guide their clinical use (Table 3). …

… Selective estrogen receptor modulators (SERMs) represent … act as estrogen agonists or
antagonists in a tissue-specific … act as blockers of the estrogen receptors, thus stimulating the …

… Taken together, these data suggest that ER modulation may be a suitable … use of SERMs
and/or “tissue selective estrogen complex” (TSEC, ie association of SERM and natural estrogen…

… essential yet relatively tissue-specific, selective progesterone receptor modulators (SPRMs) …
This effect highlights the complex functional interaction between the estrogen receptor (ER) …

… combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM…
combination with conjugated estrogens) selective estrogen receptor (ER) modulator (SERM)…

… the estrogen receptor subtype because such receptors bind … bind estrogens and selective
estrogen receptor modulators (… of the cells, and in some tissue-specific genes [43]. Excessive …

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