… polymer-drug conjugates with immune checkpoint blockade by multivalent polymer
peptide … ; and b) Drug-free macromolecular therapeutics, a new paradigm in drug delivery. …

… As shown in Figure 1A, TPP-functionalized doxorubicin (TPP-… is detached from the HPMA
copolymer due to the breakage … approximately 6–7 semitelechelic copolymer chains grafted to …

… HPMA copolymers offer high drug loading capacity due to the reactive pendant groups; …
As a polymeric carrier, HA presents multiple exploitable functional groups in its backbone (…

… functionality of the (HPMA-s-APMA)-b-GPMA block copolymer was cleaved to a free …
functionalization of cationic diblock copolymers with the uptake-promoting triphenylphosphonium …

… molecules and functional groups that could … HPMA-based polymers have a distinguished
record of clinical application 40 , having been used to modify proteins and to aid drug delivery …

… Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers
for membrane transduction and mitochondrial localization. Biomacromolecules, 2006, 7(8), …

… drug delivery, a variety of nanoparticles decorated with targeting ligands [22] including
triphenylphosphonium (… Compared with small molecular PSs, nanoparticle-based carriers provide …

… The introduction of HPMA as a carrier not only enhanced the solubility and biocompatibilities
of … This work not only proves the superiority of combined drug delivery but also provides a …

… Sensible selection of materials and physical attributes of drug carriers, real-time molecular
and functional study of the various uptake mechanisms, and the interaction of these …

… pounds are examples of the functional consequences of changing the cargo. Changes in
the … To determine if the newly synthesized variants retain this functional specificity, we next …