… domain (NOD)-like receptors (NLRs) play a pivotal role in detecting cytosolic PAMPs and
DAMPs. … diseases. We will cover NAIP proteins and their role in ligand detection and NLRC4 …

… pattern recognition receptors (… detection during infection. Thus, a number of studies have
extensively characterized the role of the NAIP/NLRC4 inflammasome during bacterial infection. …

… receptors (PRRs), which include inflammasome sensors. … of the NAIP-NLRC4 inflammasome.
Specifically, we will focus on mechanisms of ligand detection and recognition by NAIP …

… of this inflammasome, with a focus on in vivo infection and … by NAIP sensor proteins the
NAIP/NLRC4 inflammasome … -like receptor, a term often found in the inflammasome literature, but …

… immune machine formed upon the direct sensing of bacterial infection and in response to cell
… Unlike NLRC4, NAIP alone does not possess a receptor surface. The association with the …

… NLRC4, NAIP and NLRC4 also cooperatively form a single inflammasome as sensor (NAIP)
and adaptor (NLRC4) … acting as a cytoplasmic receptor to promotes the activation of NLRC4 …

… the NAIP/NLRC4 inflammasome is essential for detecting T3SS ligands in human macrophages,
it is partially required for responses to infection, as Salmonella also activated … receptors, …

… this was a result of a direct NLRC4 sensing or if other receptor could participate in this process.
… NAIP/NLRC4 inflammasome activation during infections is beneficial, whereas systemic …

… The inflammasome can also <e activated <y receptors other than NLRs, as is the case for …
of inflammasome activation (Rauch et al., 2017). Sensing <y the NAIP/NLRC4 inflammasome …

… , NAIP/NLRC4 inflammasomes are formed upon sensing the … the inflammasome pathways
involved in ligand sensing, we … between NAIP/NLRC4 and NLRP3 inflammasome receptors in …