Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis

TH Ramwadhdoebe, LGM van Baarsen… - …, 2019 - academic.oup.com
After treatment, there was incomplete depletion of LN B cells. There was a significant …
of the different B cell subsets after two rituximab infusions was changed in favour of IgD − …

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study

DM Gerlag, M Safy, KI Maijer, MW Tang… - … of the rheumatic …, 2019 - ard.bmj.com
… Indeed, treatment of patients with RA with depleting … clinical and serological biomarkers
with the arthritis hazard was … number of B cells was observed within 4 weeks after treatment in …

Early restoration of immune and vascular phenotypes in systemic lupus erythematosus and rheumatoid arthritis patients after B cell depletion

C Pérez‐Sánchez, I Cecchi… - Journal of Cellular …, 2019 - Wiley Online Library
… In this study, we aimed to explore changes in serologic parameters … following B lymphocyte
depletion in RA and SLE patients, along with their effects on the activity of other immune cells

IL-40: a new B cell-associated cytokine up-regulated in rheumatoid arthritis decreases following the rituximab therapy and correlates with disease activity …

A Navrátilová, L Andrés Cerezo, H Hulejová… - Frontiers in …, 2021 - frontiersin.org
… -40 in RA and its decrease following B cell depleting therapy. … imply its potential involvement
in RA development. Moreover, … B Cell Depletion Therapy on Serological Evidence of B Cell

… rheumatoid factor and cytokine expression by immunostimulated peripheral blood lymphocytes from patients with rheumatoid arthritis: New insights into B-cell …

JM Davis III, CS Crowson, KL Knutson… - Clinical …, 2020 - Elsevier
… the following scenario based on the role of T-helper cells in … shown to effectively deplete
activated B cells, which could be … Therapeutic success with rituximab may be related in part to …

B cell depletion treatment decreases Th17 cells in patients with rheumatoid arthritis

CA Bounia, SNC Liossis - Clinical Immunology, 2021 - Elsevier
changes in the numbers of peripheral Treg and Th17 cells. … circulating T cell subpopulations
before and after treatment with … suggest that B cell depletion in patients with RA significantly …

B-cell depletion in Rheumatoid Arthritis: clinical, biochemical and synovial predictors of response

A Mahto - 2019 - qmro.qmul.ac.uk
… of therapies available to treat rheumatoid arthritis (RA), predicting response to therapy
post-translational modifications can lead to loss of tolerance with subsequent asymptomatic …

[HTML][HTML] Rituximab levels are associated with the B cell homeostasis but not with the clinical response in patients with rheumatoid arthritis

C Diaz-Torne, MÀ Ortiz, M Sarmiento… - … of Rheumatology, 2019 - ncbi.nlm.nih.gov
B lymphocyte depletion levels on days 30 and 90 after the first … B-cell depletion therapy on
serological evidence of B-cell and plasmablast activation in patients with rheumatoid arthritis

In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response

EC de Moel, VFAM Derksen, LA Trouw, H Bang… - Arthritis research & …, 2019 - Springer
changes in autoantibody levels following treatment … diseases, these serological changes in
RA may hold promise as an … underlying the B cell autoimmune response in RA and its role in …

[HTML][HTML] … peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells

…, J Barnard, K Callahan, A Coca, B Marston… - … & rheumatology  …, 2022 - ncbi.nlm.nih.gov
B cell depletion therapy further highlights the pathogenic significance of B cells in RA (5–7). …
pathways on human B cells remain unclear as careful longitudinal studies after anti-TNF …