Change in Expression of 5-HT 6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F] 2FNQ1P
P Courault, S Emery, S Bouvard, F Liger… - … of Alzheimer's …, 2020 - content.iospress.com
… is one of the most recently identified serotonin receptors in the … of AD patients in comparison
with normal age-matched … relevant to AD, such as the entorhinal, parietal, or frontal cortex, …
with normal age-matched … relevant to AD, such as the entorhinal, parietal, or frontal cortex, …
Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies
TM Karrer, CL McLaughlin, CP Guaglianone… - … of aging, 2019 - Elsevier
… of age on serotonergic functioning. We found large negative effects of age in 5-HT-2A receptors
(largest in global cortex), … Loss of brain 5/HT/2 receptors in Alzheimer's disease. In vivo …
(largest in global cortex), … Loss of brain 5/HT/2 receptors in Alzheimer's disease. In vivo …
Serotonin Receptors as a Potential Target in the Treatment of Alzheimer's Disease
DV Eremin, EM Kondaurova, AY Rodnyy… - Biochemistry …, 2023 - Springer
… Aging has a complex effect on the central 5-HT circuitry. … There are data suggesting that
5-HT 2A and 5-HT 2C receptors … It is expressed in prefrontal cortex and different areas of the …
5-HT 2A and 5-HT 2C receptors … It is expressed in prefrontal cortex and different areas of the …
[HTML][HTML] The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer's disease: A narrative review
E Aaldijk, Y Vermeiren - Ageing Research Reviews, 2022 - Elsevier
… the serotonergic system, such as serotonin (5-HT) receptor … Firstly, it has been shown that
5-HT6 receptor antagonists have … 5-HT, while it increased IDO levels in HC and frontal cortex …
5-HT6 receptor antagonists have … 5-HT, while it increased IDO levels in HC and frontal cortex …
Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein–expressing mice
J Wihan, J Grosch, LS Kalinichenko, CP Müller… - … of aging, 2019 - Elsevier
… system, we biochemically analyzed 5-HT levels, synaptic protein, and 5-HT receptor …
prefrontal serotonergic fibers without alterations of 5-HT levels, we hypothesized that potential age…
prefrontal serotonergic fibers without alterations of 5-HT levels, we hypothesized that potential age…
Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs
MJ Millan, A Dekeyne, A Gobert, M Brocco… - …, 2020 - Elsevier
… This includes serotonin (5-HT) receptor-6 antagonists, despite … of AD and other
neurodegenerative disorders of aging. … In the hippocampus and frontal cortex, 5-HT6 receptors …
neurodegenerative disorders of aging. … In the hippocampus and frontal cortex, 5-HT6 receptors …
Serotonergic system, cognition, and BPSD in Alzheimer's disease
… is achieved via diverse expression of 14 5-HT receptor (5-HTR) … [27,28] while, in the prefrontal
cortex, 5-HT plays a major role in … Further age-dependent decreases in 5-HTR2A are also …
cortex, 5-HT plays a major role in … Further age-dependent decreases in 5-HTR2A are also …
Serotonin type 6 receptor antagonist attenuates the impairment of long-term potentiation and memory induced by Abeta
… Alzheimer’s disease (AD) is the most common cause of … from neurons of the striatum and
prefrontal cortex of rats [77]. The … Serotonin 5-HT6 receptor blockade reverses the age-related …
prefrontal cortex of rats [77]. The … Serotonin 5-HT6 receptor blockade reverses the age-related …
Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against Amyloid-β toxicity, memory preservation, and …
A Siwek, M Marcinkowska, M Głuch-Lutwin… - European Journal of …, 2024 - Elsevier
… Alzheimer's disease patients revealed disturbances in 5-HT … for molecular recognition with
5-HT 6 receptor, we selected … of BDNF in rat prefrontal cortex and hippocampus after FST. …
5-HT 6 receptor, we selected … of BDNF in rat prefrontal cortex and hippocampus after FST. …
Progress in investigational agents targeting serotonin-6 receptors for the treatment of brain disorders
R Nirogi, P Jayarajan, A Shinde, AR Mohammed… - Biomolecules, 2023 - mdpi.com
… 5-HT 6 receptor antagonists in the treatment of agitation in dementia of the Alzheimer’s
type. … and glutamatergic neurotransmission in the rat hippocampus and prefrontal cortex [50,51]. …
type. … and glutamatergic neurotransmission in the rat hippocampus and prefrontal cortex [50,51]. …