… Serotonin [5-hydroxytryptamine (5-HT)] is synthesized from tryptophan … pancreatic β cells,
5-HT plays pivotal roles in compensating for physiological insulin resistance during pregnancy…

… serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an
autocrine/paracrine manner during … are simultaneously increased during pregnancy. 5-HT …

… While β-cell mass increases during pregnancy and starts to return … β-cell mass during this
period is regulated remains unclear. To address this issue in mice, we quantified β-cell mass …

… Given the importance to understand beta cell serotonin during pregnancy, and the fact that
… of serotonin/Htr2b receptor-regulated beta cell proliferation during pregnancy using three …

… endocrine factor regulating maternal β-cell insulin secretion … in regulating pancreas endocrine
function during pregnancy. … to serotonin receptors on β-cells and regulates GSIS during …

… secretion during pregnancy48; thus, pregnant Htra3a knockout mice develop impaired
glucose tolerance despite normal β-cell mass. With this in mind, it might be speculated that β-cell–…

… This study identifies a role of GH/GH receptor/5-HT/HTR2B signaling in the control of β cell
mass expansion during puberty and identifies a mechanistic link between pubertal obesity …

… In addition, 5-HT has been implicated in beta-cell adaptive responses to pregnancy, with
reports of enhanced insulin secretion and increased beta-cell mass to compensate for …

… in pregnant mice and tested the impact of deficiency on serotonin levels in pancreatic islets.
… new insights into the role of vitamin B6 on pancreatic islet physiology during pregnancy. …

… In contrast, due to a scarcity of pancreas samples from pregnant humans, these adaptive …
Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 2010; 16(7): 804-8. …