[HTML][HTML] Smilax china L. Polysaccharide Alleviates Oxidative Stress and Protects From Acetaminophen-Induced Hepatotoxicity via Activating the Nrf2-ARE Pathway

K Wang, L Yang, J Zhou, X Pan, Z He, J Liu… - Frontiers in …, 2022 - frontiersin.org
… effect on oxidative stress in the liver, Nrf2 may be a promising target for attenuating AILI. …
Nrf2 in SCLP-mediated protection against AILI. Our results showed that SCLP upregulated Nrf2

E Se tea alleviates acetaminophen-induced liver injury by activating the Nrf2 signaling pathway

J Zhang, M Li, T Zhao, J Cao, Y Liu, Y Wang… - Food & Function, 2022 - pubs.rsc.org
… In the current study, EW and EA pretreatment especially in the EAH group upregulated the
expressions of nuclear Nrf2 and the relative indicators (HO-1, NQO1, SOD2, Gpx1, GCLC and …

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway

P Shen, L Han, G Chen, Z Cheng, Q Liu - Inflammation, 2022 - Springer
Nrf2 translocates to the nucleus under ROS stimulation and binds to antioxidant … and
upregulated Nrf2, HO-1, and NQO1 expression. These results suggest that emodin alleviates Nrf2-…

[HTML][HTML] Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity: Role of Nrf2/NF-κB and JNK/ASK-1 signaling pathways

GA Mohamed, DS El-Agamy, HM Abdallah, IA Sindi… - Heliyon, 2024 - cell.com
… it promoted the activation of Nrf2 signaling. Additionally, KSG … against APAP-produced ALI
via modulation of Nrf2/NF-κB and … kinase 1 attenuates acetaminophen-induced liver injury by …

Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice

MC Indumathi, K Swetha, KV Abhilasha… - … Trace Element Research, 2024 - Springer
… on APAP-induced hepatotoxicity and successfully ameliorated the oxidative stress caused
by APAP. In addition, we observed that selenium upregulated Nrf2 and heme-oxygenase-1 (…

Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease

R Jayasuriya, U Dhamodharan, D Ali, K Ganesan, B Xu… - Phytomedicine, 2021 - Elsevier
Shikonin was estimated to regulate Nrf2 through PI3K/Akt/GSK 3β pathway and attenuate
APAP-induced hepatic toxicity … dysfunction and upregulated antioxidant signaling pathways in …

[HTML][HTML] … Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Crateva unilocularis Buch.) against Acetaminophen-Induced Liver Injury in …

M Shan, Q Ma, Y Sun, F Gao, S Cai - Foods, 2023 - mdpi.com
attenuate oxidative stress and protect the hepatocytes from oxidative stress injury through the
Nrf2/… reduced APAP-induced hepatotoxicity by blocking the binding of Nrf2 to Keap1 [44]. In …

[HTML][HTML] Correction: Li et al. Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling. Molecules 2019, 24 …

H Li, Y Chen, J Zhang, X Chen, Z Li, B Liu, L Zhang - Molecules, 2023 - mdpi.com
… In addition, the Nrf2 band of Figure 4A was mistakenly selected, as it was the short
exposure of the Nrf2 band in Figure 4B. The authors have provided correct versions of …

[HTML][HTML] Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review

X Li, R Lao, J Lei, Y Chen, Q Zhou, T Wang, Y Tong - Molecules, 2023 - mdpi.com
… is primarily dependent on the activation of the Nrf2 signaling … (MRPs) 1 and 3, upregulate
Nrf2 and its target genes, inhibit the … Attenuated the activation of the JNK pathway and reduced …

Therapeutic potential of isorhamnetin following acetaminophen-induced hepatotoxicity through targeting NLRP3/NF-κB/Nrf2

AM Rousta, A Shahmohammadi, Z Mehrabi… - Drug …, 2022 - thieme-connect.com
… LPS challenge in human gingival fibroblasts through up-regulation of Nrf2 signaling [15].
However, … model of lung injury through attenuation inflammatory cytokines, oxidative stress and …