… against APAP-induced hepatotoxicity via the PI3K/Akt/Nrf2 pathway. … acute hepatotoxicity
mice via activating PI3K/Akt/Nrf2 pathway, … In our study, tempol treatment upregulated levels of …

… shikonin activated Nrf2 in vitro, we further assessed whether Nrf2 was involved in the protective
effects of shikonin … shikonin attenuated DOX-induced upregulation of Bax and the down-…

… Shikonin inhibited the upregulation of proinflammatory cytokines (IL-6, IL-1β, and TNF-α),
which were found to be elevated in BPH prostate tissues. It is well-established that oxidative …

… and inflammatory response via upregulation of heme oxygenase-… Shikonin attenuates
acetaminophen-induced acute … acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-…

… GSK3)β/Nrf2 activation [46]. Tumor suppressor p53 activation can attenuate hepatic toxicity.
… Antioxidant molecules like quercetin, Shikonin, Corilagin, Licochalcone, Ginsenoside-Rg1 …

… transporter function in the proximal nephron via NHE3 downregulation [23]. Furthermore, it
is … complex caused by NHE3 downregulation. However, shikonin treatment significantly and …

… The protection of neurons from oxidative damage depends on the up-regulation of
antioxidant response mediated by Nrf2/ARE. The redox-sensitive transcription factor …

… JuB treatment upregulated the levels of total Nrf2, facilitated its nuclear translocation,
upregulated the … signal pathway is considered an attractive target for attenuating DILI, and drugs …

… Sarmentosin attenuated APAP-induced oxidative damage of … Therefore, we concluded that
downregulation of Nrf2 activation … -TEMPO against acetaminophen-induced hepatotoxicity in …

… Shikonin attenuates acetaminophen-induced acute … Licochalcone A upregulates 494 Nrf2
antioxidant pathway and … alleviate acetaminophen-induced liver injury by activating Nrf2 534 …