The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers

H Wang, L Chi, F Yu, H Dai, X Si, C Gao, Z Wang… - Bioorganic & Medicinal …, 2022 - Elsevier
… , 8 Mitogen-activated extracellular signal-regulated kinase 1 and 2 (MEK1/2) are a part of
MAPK/ERK1/2 signal transduction … fundamental cellular processes in response to extracellular …

… in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway

D Liu, M Zhang, J Tian, M Gao, M Liu, X Fu… - Journal of …, 2022 - journals.lww.com
… WNT-inducible signalling pathway protein-1 can accelerate cell … signal-regulated kinase,
mitogen-activated extracellular signal-regulated kinase and focal adhesion kinase pathway

Direct early growth response-1 knockdown decreases melanoma viability independent of mitogen-activated extracellular signal-related kinase inhibition

DR Miley, CM Andrews-Pfannkoch, JS Pulido… - Melanoma …, 2023 - journals.lww.com
kinase (MAPK) pathway is a key factor in melanoma proliferation [ 4 ]. The MAPK pathway,
also known as the RAS/RAF/MEK/ERK pathway… of other molecules which regulate melanoma …

Regulation of c-Fos gene transcription by stimulus-responsive protein kinases

AK Dalhäusser, OG Rössler, G Thiel - Gene, 2022 - Elsevier
… of mitogen-activated/extracellular signal responsive kinase … Stimulus-responsive protein
kinases function as signal transducers that … We therefore assessed the transcriptional response

[HTML][HTML] UDP-glucose sensing P2Y14R: A novel target for inflammation

JZ Zhang, NR Shi, JS Wu, X Wang, P Illes, Y Tang - Neuropharmacology, 2023 - Elsevier
… activated protein kinases (MAPKs), and signal transducer and … R signaling pathways that
modulate inflammatory responses … the mitogen-activated extracellular signal-regulated kinase (…

Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway

A Mai, SW Ye, JY Tu, J Gao, ZF Kang… - Environmental …, 2023 - Wiley Online Library
signal-regulated kinase (ERK) signaling pathway, leading to TMZ resistance. Mitogen-activated
extracellular signal-regulated kinase (… of the RAS/RAF/ERK pathway. A combination of …

Unraveling the interplay between RAS/RAF/MEK/ERK signaling pathway and autophagy in cancer: From molecular mechanisms to targeted therapy

Y Huang, Y Zhen, Y Chen, S Sui, L Zhang - Biochemical Pharmacology, 2023 - Elsevier
… , apoptosis and signaling transduction. Autophagy is an … of mitogen-activated extracellular
signal-regulated kinase (… state is initiated in response to extracellular signals and stimuli. …

Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis

X Wang, C Dai, Y Yin, L Wu, W Jin, Y Fu… - Journal of Zhejiang …, 2021 - Springer
… Dysregulated crosstalk between different signaling pathways … the mitogen-activated
extracellular signal-regulated kinase (… the Janus kinase 2 (JAK2)/signal transducer and activator of …

MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents

I Peluso, NS Yarla, R Ambra, G Pastore… - Seminars in cancer …, 2019 - Elsevier
… In particular, the role of MAPKs pathway in cancer led to the … kinases serine/threonine-protein
kinase B-raf (BRAF) and the mitogen-activated extracellular signal-regulated kinase (MEK). …

[HTML][HTML] IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF-κB Pathway

Z Tu, W Wei, F Zeng, W Wang, Y Zhang… - The American Journal of …, 2024 - Elsevier
… the mitogen-activated extracellular signal-regulated kinase (… IL-6/IL-6 receptor–mediated
signal transduction molecules … /NF-κB signaling pathway in keratinocytes in response to IL-6, …