Cross-talk between colon cells and macrophages increases ST6GALNAC1 and MUC1-sTn expression in ulcerative colitis and colitis-associated colon cancer

M Kvorjak, Y Ahmed, ML Miller, R Sriram… - Cancer immunology …, 2020 - AACR
… -sTn glycoform, which is associated with colonic inflammation and cancer. A computational
model demonstrated the signaling, cross-talk and dynamics involved in regulating gene …

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

C Heichler, K Scheibe, A Schmied, CI Geppert… - Gut, 2020 - gut.bmj.com
signal transducer and activator of transcription 3 (STAT3) targeting, we evaluated STAT3
signalling in fibroblasts during colorectal … a key role in the cross-talk to the tumour epithelium. …

The role of autophagy in liver cancer: crosstalk in signaling pathways and potential therapeutic targets

J Cui, HM Shen, LHK Lim - Pharmaceuticals, 2020 - mdpi.com
… Autophagy plays a dual role in liver cancer development via several critical signaling
Here, we review the signaling pathways involved in the cross-talk between autophagy and …

Mechanisms of immunosuppression in colorectal cancer

Y Zhang, A Rajput, N Jin, J Wang - Cancers, 2020 - mdpi.com
… preneoplastic lesions and its expression is increased by oxidative stress through signal
transducer and activator of transcription 3 (STAT3) in CRC cells [64]. However, the cell surface-…

The Role of Dyslipidemia in Colitis‐Associated Colorectal Cancer

K Chen, J Guo, T Zhang, J Gu, H Li… - Journal of …, 2021 - Wiley Online Library
… cells in the tumor microenvironment through the cross-talk between tumor cells and …
fatty acids also regulate signaling transduction through an array of signaling molecules [78]. …

Wnt/β-catenin signal transduction pathway in prostate cancer and associated drug resistance

C Wang, Q Chen, H Xu - Discover Oncology, 2021 - Springer
… modulate this pathway in prostate cancer. Finally, we … cancer as it is a challenging facet
of therapy development due to the complexity of signaling pathways interaction and cross-talk. …

Overview of cell signaling pathways in cancer

AJ Harvey - Predictive Biomarkers in Oncology: Applications in …, 2019 - Springer
Signal transduction defines the precise series of molecular … as there is considerable
cross talk between such subcircuits. … Elevated EGFR signaling in colorectal cancer can be …

Targeting receptor kinases in colorectal cancer

M García-Aranda, M Redondo - Cancers, 2019 - mdpi.com
… the subsequent inactivation of downstream signal transduction. Since abnormal … at different
stages of signal propagation [114]. In short, it seems that MAPK/RAS and PI3K/AKT cross-talk

[HTML][HTML] Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment

A Attiq, S Afzal - Frontiers in pharmacology, 2023 - frontiersin.org
… proliferation and motility of colorectal cancer cells, suggesting a … cancer cells to evade
apoptosis and promote cell growth via activating transcriptional factors, including signal transducer

MicroRNA-assisted hormone cell signaling in colorectal cancer resistance

C Massaro, E Safadeh, G Sgueglia, HG Stunnenberg… - Cells, 2020 - mdpi.com
… of hormone signaling pathways and their cross-talk with other signaling cascades inside CRC
cells … signaling comprises hormone binding to its receptor and signal transduction through