[HTML][HTML] Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
… , extracellular signal-regulated kinases (ERK) signaling, and endoplasmic reticulum (ER) …
of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in …

Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum

DQ Chen, G Cao, H Zhao, L Chen… - … advances in chronic …, 2019 - journals.sagepub.com
… However, the inhibitory effects of combined melatonin and PAA therapy against other
profibrotic signal pathways, including interleukin, hedgehog, and the connective tissue growth …

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice

G Cao, H Miao, Y Wang, D Chen, X Wu… - Acta Pharmacologica …, 2022 - nature.com
… mediated renal fibrosis through EMT and MMT by activating AhR signalling pathways and …
that GFA treatment attenuated renal fibrosis by regulating the AhR signalling pathway after MP …

Involvement of miR‐27a‐3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress

L Wu, Q Wang, F Guo, X Ma, J Wang… - Journal of Cellular …, 2021 - Wiley Online Library
… 3.2 Effect of miR-27a-3p on renal fibrosis in db/db mice Renal fibrosis is a remarkable
feature of DN, we thus further investigated the role of miR-27a-3p in renal fibrosis. As shown in …

Pioglitazone protects tubular cells against hypoxia/reoxygenation injury through enhancing autophagy via AMPK-mTOR signaling pathway

X Xi, C Zou, Z Ye, Y Huang, T Chen, H Hu - European journal of …, 2019 - Elsevier
… protein kinase(AMPK) signaling pathways. Therefore, this study … in a normal rat kidney
proximal tubular cells model of hypoxia/… -mammalian target of rapamycin (AMPK-mTOR) pathway. …

[HTML][HTML] Transcription factor-mediated signaling pathways' contribution to the pathology of acute lung injury and acute respiratory distress syndrome

Z Chen, S Hua - American journal of translational research, 2020 - ncbi.nlm.nih.gov
… Wnt/β-catenin-TCF/LEF signaling functions in the regulation of genes involved in pulmonary
fibrosis [57-59]. Hypoxia induces HIFs stabilization, which can benefit lung protection. The …

Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues

H Miao, XQ Wu, DD Zhang, YN Wang, Y Guo… - Pharmacological …, 2021 - Elsevier
pathway regulates renal fibrosis via TAZ-inducedrenal fibrosis after acute kidney injury
[89]. Furthermore, the activation of S1PR promotes lung fibrosis via the Smad signalling pathway

[HTML][HTML] NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis

J Zhou, S Liu, L Guo, R Wang, J Chen, J Shen - BMC nephrology, 2020 - Springer
… NMDAR activated CaMKII/ERK in C57BL/6 mice with UUO-induced renal fibrosis. a
Western blots for the expression levels of total and p-CaMKII and total and p-ERK and (b) band …

[HTML][HTML] Induction of autophagy by pterostilbene contributes to the prevention of renal fibrosis via attenuating NLRP3 inflammasome activation and epithelial …

YJ Wang, YY Chen, CM Hsiao, MH Pan… - Frontiers in Cell and …, 2020 - frontiersin.org
… NLRP3 inflammasome may attenuate renal inflammation and fibrosis; thus, NLRP3 … induction,
nucleation, elongation, and fusion that are tightly regulated by various signaling pathways

Hypoxia and transforming growth factor β1 regulation of long non‐coding RNA transcriptomes in human pulmonary fibroblasts

LK Senavirathna, C Huang, S Pushparaj… - Physiological …, 2020 - Wiley Online Library
… Using KEGG pathway analysis, we further analyzed signaling pathways regulated by … Our
KEGG pathway analysis showed that hypoxia upregulated the genes in TGFβ signaling and …