[HTML][HTML] SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

C Li, L Du, Y Ren, X Liu, Q Jiao, D Cui, M Wen… - … & clinical cancer …, 2019 - Springer
… and PDCD4 showed negative correlation in human breast cancer tissues. Radiotherapy
combine with SKP2 inhibitor SMIP004 showed significant inhibitory effects on breast cancer

[HTML][HTML] A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer

LWR Fong, J Lee, HK Lin, NT Ueno, S Zhang - Scientific reports, 2022 - nature.com
… We graphed the survival curves of the two groups using the Kaplan–Meier method and
determined the significance of the survival differences using the log-rank method. Since …

The Skp2 pathway: a critical target for cancer therapy

Z Cai, A Moten, D Peng, CC Hsu, BS Pan… - Seminars in cancer …, 2020 - Elsevier
… to determine the physiological significance or clinical relevance of these substrates for …
Moreover, in Her2-positive breast cancer patients, enhanced Skp2 expression is positively …

Targeting TAZ-driven human breast cancer by inhibiting a SKP2-p27 signaling axis

H Shen, N Yang, A Truskinovsky, Y Chen… - Molecular Cancer …, 2019 - AACR
… the perturbation of SKP2 in high TAZ-expressing BLBC cells … -mediated SKP2 expression,
we inhibited SKP2 expression … Having established the relevance of SKP2 for TAZ-induced …

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

G Wang, J Wang, A Chang, D Cheng, S Huang, D Wu… - Oncogene, 2020 - nature.com
… Her2 promotes breast cancer early dissemination by … lesion breast cancer models, Her2
inhibits p38 by inducing Skp2 through … ns not significant, *p < 0.05 vs indicated controls in one-…

RNA‐binding protein NONO promotes breast cancer proliferation by post‐transcriptional regulation of SKP2 and E2F8

K Iino, Y Mitobe, K Ikeda, K Takayama… - Cancer …, 2020 - Wiley Online Library
… To clarify the clinical significance of NONO in breast cancer, we carried out immunohistochemical
analysis of NONO in 127 primary breast cancer tissue samples from patients. Among …

[HTML][HTML] PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis

M Elfoly, JY Mirza, A Alaiya, AA Al-Hazzani… - Cancer Cell …, 2024 - Springer
SKP2 in promoting PD-L1-mediated proliferation. Finally, immunohistochemistry in 74 breast
cancer … a highly statistically significant correlation between SKP2 and PD-L1 expression (p …

[HTML][HTML] Emerging roles of SKP2 in cancer drug resistance

T Wu, X Gu, H Cui - Cells, 2021 - mdpi.com
primary breast cancer [49]. Detailed analysis has shown that Skp2 knockdown leads to a
significant … associated with Skp2 expression in paclitaxel-resistant (PR) breast cancer cells, and …

[HTML][HTML] Differential expression of HER2 and SKP2 in benign and malignant colorectal lesions

M Moussa, A Badawy, N Helal, F Hegab… - … Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
… The food and drug administration (FDA) approved scoring system for breast cancer which is
… Our results showed a high statistically significant SKP2 expression in CRC group compared …

Curcumol suppresses triple-negative breast cancer metastasis by attenuating anoikis resistance via inhibition of skp2-mediated transcriptional addiction

CL Li, CW Huang, CJ Ko, SY Fang… - Anticancer …, 2020 - ar.iiarjournals.org
… : Triple-negative breast cancer (TNBC) is a unique subtype that lacks expression of several
… node invasion and distal metastasis among all breast cancers. Anoikis resistance is the …