Integrated metabolomics and network pharmacology strategy for ascertaining the quality marker of flavonoids for Sophora flavescens

L Chen, X Huang, H Wang, J Shao, Y Luo… - … and Biomedical Analysis, 2020 - Elsevier
… was used for the simultaneous determination of 6 flavonoids … activity against two kinds of
cells, while trifolirhizin, genistein … Also, trifolirhizin is reported to inhibit the proliferation of A549 …

Bioactive flavonoids: A comprehensive review on pharmacokinetics and analytical aspects

K Billowria, R Ali, NK Rangra, R Kumar… - Critical Reviews in …, 2022 - Taylor & Francis
… In the qualitative and the quantitative study, Chang-Ming et al. explains about the analysis
… , in which the trifolirhizin, quercetin, maackiain, sophoranone and the sophoranochromene …

The pharmacology of the genus Sophora (Fabaceae): An updated review

SH Aly, AM Elissawy, OA Eldahshan, MA Elshanawany… - Phytomedicine, 2019 - Elsevier
… -3 expression and elevation of Bcl-2/Bax ratio, if administered to rats at doses of 30 mg/kg
as revealed by Western blot analysis and immunofluorescence staining. Besides, it diminished …

Trifolirhizin relieves renal injury in a diabetic nephropathy model by inducing autophagy and inhibiting oxidative stress through the regulation of PI3K/AKT/mTOR …

Y Xin, X Xu, X Yang, Y Chen, D Zhu - Tropical Journal of Pharmaceutical …, 2022 - ajol.info
… Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from
sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells. …

… Purification of Total Flavonoids from Sophora tonkinensis Gagnep. by Macroporous Resin Column Chromatography and Comparative Analysis of Flavonoid Profiles …

M Hou, W Hu, Z Xiu, A Jiang, L Men, K Hao, X Sun… - Molecules, 2019 - mdpi.com
… In addition, the HPLC-PAD analysis indicated that the contents of the six flavonoids (rutin,
maackiain, trifolirhizin, quercetin, formononetin, and quercitrin) in the S. tonkinensis extracts …

Systematic analysis of chemical profiles of Sophorae tonkinensis Radix et Rhizoma in vitro and in vivo using UPLC‐Q‐TOF‐MSE

W Yuan, Z Huang, S Xiao, Y Zhang… - Biomedical …, 2022 - Wiley Online Library
… Matrine, oxymatrine, cytisine, maackiain, and trifolirhizin were purchased from Chengdu
Derick Biotechnology Co., Ltd. (Sichuan, China). Sophocarpine, oxysophocarpine, and glabrol …

… Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

YF Zheng, SH Bae, Z Huang, SU Chae, SJ Jo, HJ Shim… - Pharmaceutics, 2020 - mdpi.com
… Three-day validations were performed to confirm the effectiveness of the LC-MS/MS
system for simultaneous determination of the nine P450-selective substrate metabolites at the …

[PDF][PDF] In vitro and in vivo human gastric cancer inhibition by Trifolirhizin is facilitated via autophagy, mitochondrial mediated programmed cell death, G2/M phase cell …

K Zhang, W Liu, Z Qu, Q Liu, J Chen, R Tao, Y Deng… - J BUON, 2019 - jbuon.com
… effects of Trifolirhizin in vivo and found that Trifolirhizin could inhibit the growth of
xenografted tumors, indicative of the potential of Trifolirhizin in the treatment of gastric cancer. …

[PDF][PDF] PK Analysis of Antitumor B in Patients with Oral Cancer

SJ Wong - cdn.clinicaltrials.gov
… oral cancer cell line SCC2095: fraxinellone, dictamnine and maackiain (see Fig. 4 …
Trifolirhizin is also expected to be highly active because it is rapidly bio transformed to maackiain