Deep profiling of cellular heterogeneity by emerging single‐cell proteomic technologies
… and cell–cell interactions and highlighting tumor heterogeneity. However, the mass cytometry
approaches … probes. Another distinct advantage of the droplet-based microfluidics for …
approaches … probes. Another distinct advantage of the droplet-based microfluidics for …
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
… we profile 233,591 single cells from patients with lung, colorectal, ovary and breast cancer (n
= 36) and construct a pan-cancer … Our approach was less successful for cancer cells, which …
= 36) and construct a pan-cancer … Our approach was less successful for cancer cells, which …
Single-cell analysis of circulating tumor cells: why heterogeneity matters
… tool for assessing tumor heterogeneity and for revealing … to in-depth sequencing to probe
only CTCs with yields of DNA … resolving cellular heterogeneity, single-cell approaches may …
only CTCs with yields of DNA … resolving cellular heterogeneity, single-cell approaches may …
An integrated gene expression landscape profiling approach to identify lung tumor endothelial cell heterogeneity and angiogenic candidates
… of endothelial cells (ECs) to block tumor … cancer using single-cell RNA sequencing in
combination with orthogonal bulk multi-omics approaches to provide a molecular atlas of tumor EC (…
combination with orthogonal bulk multi-omics approaches to provide a molecular atlas of tumor EC (…
Applications of single-cell sequencing in cancer research: progress and perspectives
Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
… cells and immune cells, tumor heterogeneity, circulating … and immune cells because it can
probe cellular and … The 10X Genomics platform, which is based on a microfluidics approach, is …
probe cellular and … The 10X Genomics platform, which is based on a microfluidics approach, is …
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis
K Xu, R Wang, H Xie, L Hu, C Wang, J Xu, C Zhu, Y Liu… - Oncogenesis, 2021 - nature.com
… future studies on tumor heterogeneity and pave … probe the genomic profile of breast cancer,
we applied inferCNV algorithm to analyze the copy-number variants (CNVs) of a single cell…
we applied inferCNV algorithm to analyze the copy-number variants (CNVs) of a single cell…
Tumor heterogeneity in glioblastomas: from light microscopy to molecular pathology
… molecular alterations in DNA, RNA, and proteins observed at individual cells. … -tumor
heterogeneity of GBMs, which directly affects prognosis and response to treatment. Our approach …
heterogeneity of GBMs, which directly affects prognosis and response to treatment. Our approach …
Inter-and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling
… probes (median of 10 probes/target mRNA) for each gene of interest for a total of 18,120
probes, … In this study, we used a robust approach for quantitative spatial molecular profiling to …
probes, … In this study, we used a robust approach for quantitative spatial molecular profiling to …
Addressing cellular heterogeneity in tumor and circulation for refined prognostication
… an unanticipated impact of intratumor heterogeneity (ITH) … probe heterogeneity within the
CTC population, we further isolated and analyzed 24 single cells of 7 different lung cancer cell …
CTC population, we further isolated and analyzed 24 single cells of 7 different lung cancer cell …
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
H Song, HNW Weinstein, P Allegakoen… - Nature …, 2022 - nature.com
… To probe the diversity of cell types and transcriptional states … the cellular state heterogeneity
revealed by single-cell … prostate cancer-associated club cells, we used established methods …
revealed by single-cell … prostate cancer-associated club cells, we used established methods …