… Carriers of small isoforms with up to 22 kringle IV domains … kringle consisting of two short
exons, spaced by a mostly ≈4 … by several functional single nucleotide polymorphisms (SNPs) (…

… single nucleotide polymorphisms (… -kringle IV (14K), 6kringle IV (6K), and a construct
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…

… for apolipoprotein(a) [apo(a)], which consists of 10 different kringle IV domains (KIV-1 to
KIV-10)… repeat (STR) located 1.3 kb upstream from the first exon of LPA (hg19 chr6:161,086,617–…

… single nucleotide polymorphisms (… -kringle IV (14K), 6kringle IV (6K), and a construct
containing KIV10, KV, and the protease-like domain (10-P) in the pRK5 plasmid, and a wildtype apo(…

… Approximately 90#x0025; of Lp(a) variance is controlled by the LPA gene, which contains
a 5.6-kb-large copy number variation [kringle IV type 2 (KIV-2) repeat] that generates >40 …

… The kringle IV type 2 (KIV-2) domain is further expanded resulting … single-nucleotide
polymorphisms [SNPs] in the protease … on exon 26; in our study, we identified this variant in 4 …

… Imaging of the recombinant apo(a) proteins in conjunction with … correct folding of the apo(a)
kringle structure and mutations at … (a) kringles IV types 6 to 10 domain affect Lp(a) plasma …

… a kringle-V (KV) and a protease domain. The KIV elements of … coding exons are highly
homologous to the respective exons … of KIV repeats or single nucleotide polymorphisms (SNPs) …

… (GWAS) identified more than 200 single nucleotide polymorphisms (SNPs), which might …
, including both exons 4 and 5 encoding kringle IV type 2 (KIV2) protein domain, represents its …

… Apo(a) lacks the tail domain and kringles 1–3 and consists of multiple copies of a kringle 4-like
sequence (IV 1 to IV 10 ), a kringle … arising from alternative splicing or exon skipping). The …